Evidence map›Paper›PMID 39969638›Full record

ArticleJournal of neurology2025

Quantifying neurodegeneration within subdivisions of core motor pathways in amyotrophic lateral sclerosis using diffusion MRI.

Hannes Almgren, Colin J Mahoney, William Huynh, Arkiev D'Souza, Sienna Berte, Jinglei Lv, Chenyu Wang, Matthew C Kiernan, Fernando Calamante, Sicong Tu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hannes AlmgrenBrain & Mind Centre, The University of Sydney, Sydney, Australia.ORCID http://orcid.org/0000-0001-9428-8348
Colin J MahoneyDepartment of Neurology, Liverpool Hospital, Sydney, Australia.
William HuynhBrain & Mind Centre, The University of Sydney, Sydney, Australia.
Arkiev D'SouzaBrain & Mind Centre, The University of Sydney, Sydney, Australia.
Sienna BerteBrain & Mind Centre, The University of Sydney, Sydney, Australia.
Jinglei LvBrain & Mind Centre, The University of Sydney, Sydney, Australia.
Chenyu WangBrain & Mind Centre, The University of Sydney, Sydney, Australia.
Matthew C KiernanNeuroscience Research Australia, University of NSW, Sydney, Australia.
Fernando Calamante *Brain & Mind Centre, The University of Sydney, Sydney, Australia. fernando.calamante@sydney.edu.au.
Sicong Tu *Brain & Mind Centre, The University of Sydney, Sydney, Australia. sicong.tu@sydney.edu.au.

Funding

NHMRC APP2029871NHMRC Practitioner Fellowship 1156093
6 · The paper itself

Abstract

backgroundDiffusion MRI is sensitive to white matter changes in amyotrophic lateral sclerosis (ALS). The current study aimed to establish disease profiles across core motor pathways, and their relevance to clinical progression in ALS.

methodsSixty-five participants (ALS = 47; Control = 18) were recruited for the study. White matter integrity of motor, somatosensory, and premotor subdivisions within the corticospinal tract and corpus callosum were quantified by fibre density, fibre-bundle cross-section, structural connectivity, and fractional anisotropy. Analyses focused on identifying diffusion metrics and tract profiles sensitive to ALS pathology, and their association with clinical progression.

resultsReduced fibre density of the motor subdivision of the corpus callosum (CC) and corticospinal tract (CST) demonstrated best performance in classifying ALS from controls (area-under-curve: CC

conclusionCurrent findings suggest that ALS does not uniformly impact the corticospinal tract and corpus callosum. There is a preferential disease profile of neurodegeneration mainly impacting primary motor fibres. Microstructural white matter abnormality indicated presence of ALS pathology while macrostructural white matter abnormality was associated with severity of functional impairment. Quantification of white matter abnormality in corticospinal tract and callosal subdivisions holds translational potential as an imaging biomarker for neurodegeneration in ALS.

Indexed as

Amyotrophic Lateral SclerosisCorpus CallosumDiffusion Magnetic Resonance ImagingPyramidal TractsWhite MatterAdultAgedDiffusion Tensor ImagingDisease ProgressionFemaleHumansMaleMiddle AgedAmyotrophic lateral sclerosisCorpus callosumCorticospinal tractDiffusion MRIMotor neuron disease

Identifiers

PMID39969638
PMCPMC11839792

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.