ArticleJournal of neurology2025
Associations between connectivity in functional brain networks and gait speed in older adults with and without multiple sclerosis.
Article in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Resting-state functional magnetic resonance imaging study on the effects of visual status on walking-related brain functions in healthy young adults.Chinese medical journal · 2026Article
- Mild cognitive impairment impacts association of functional brain connectivity with cognition in older adults with and without multiple sclerosis.GeroScience · 2026Article
- Resting-state functional connectivity correlates of gait and turning performance in multiple sclerosis: a multivariate pattern analysis.Scientific reports · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectiveTo assess whether resting-state functional connectivity (RSFC) brain networks are associated with gait speed in a sample of older adults with and without multiple sclerosis (MS).
methodsOlder adults with MS (OAMS: n = 82, mean age = 64.4 ± 4.1 years) and controls (n = 85, mean age = 68.6 ± 7.1 years) underwent brain MRI, cognitive assessment, and motor testing. RSFC brain networks were computed from resting-state functional scans based on a data-driven approach. The timed-25-foot-walk test (T25FW), an established measure of disability in aging and clinical populations, served as the outcome measure.
resultsAnalyses adjusted for confounders revealed that faster gait speed was significantly associated with higher RSFC in left fronto-parietal (p = 0.002) network in the full cohort. Among OAMS, significant associations between faster gait speed and higher RSFC were found in left fronto-parietal (p = 0.002), cerebellar (p = 0.023), and language (p = 0.046) networks. In contrast, among control participants, there were no significant associations between RSFC and gait speed.
conclusionIn aging, greater functional brain support of walking speed, operationalized using RSFC in empirically derived networks, is required in MS compared to healthy control participants.
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Registered trials
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