Evidence map›Paper›PMID 39969596›Full record

ArticleActa neurochirurgica2025

Three-dimensional amide proton transfer (APT) imaging appliable to navigation surgery can present comparable metabolic activity of glioblastoma to

Akihiro Inoue, Hideaki Watanabe, Kosuke Kusakabe, Masahiro Nishikawa, Sho Ohtsuka, Yasuhiro Shiraishi, Mashio Taniwaki, Yoshihiro Takimoto, Masaki Matsumoto, Mitsuharu Miyoshi and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neurochirurgica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Akihiro InoueDepartment of Neurosurgery, Ehime University School of Medicine, 454 Shitsukawa, Toon, Ehime, 791-0295, Japan. iakihiro3@gmail.com.ORCID 0000-0002-7438-2369
Hideaki WatanabeDepartment of Neurosurgery, Ehime University School of Medicine, 454 Shitsukawa, Toon, Ehime, 791-0295, Japan.
Kosuke KusakabeDepartment of Neurosurgery, Ehime University School of Medicine, 454 Shitsukawa, Toon, Ehime, 791-0295, Japan.
Masahiro NishikawaDepartment of Neurosurgery, Ehime University School of Medicine, 454 Shitsukawa, Toon, Ehime, 791-0295, Japan.
Sho OhtsukaDepartment of Neurosurgery, Ehime University School of Medicine, 454 Shitsukawa, Toon, Ehime, 791-0295, Japan.
Yasuhiro ShiraishiDivision of Neurology, Ehime University Hospital, 454 Shitsukawa, Toon, Ehime, 791-0295, Japan.
Mashio TaniwakiDivision of Diagnostic Pathology, Ehime University Hospital, 454 Shitsukawa, Toon, Ehime, 791-0295, Japan.
Yoshihiro TakimotoDivision of Neurology, Ehime University Hospital, 454 Shitsukawa, Toon, Ehime, 791-0295, Japan.
Masaki MatsumotoDivision of Neurology, Ehime University Hospital, 454 Shitsukawa, Toon, Ehime, 791-0295, Japan.
Mitsuharu MiyoshiGE HealthCare, 4-7-127 Asahigaoka, Hino, Tokyo, 191-8503, Japan.
Seiji ShigekawaDepartment of Neurosurgery, Ehime University School of Medicine, 454 Shitsukawa, Toon, Ehime, 791-0295, Japan.
Riko KitazawaDivision of Neurology, Ehime University Hospital, 454 Shitsukawa, Toon, Ehime, 791-0295, Japan.
Teruhito KidoDepartment of Radiology, Ehime University School of Medicine, 454 Shitsukawa, Toon, Ehime, 791-0295, Japan.
Takanori OhnishiDepartment of Neurosurgery, Washoukai Sadamoto Hospital, 1-6-1 Takehara, Matsuyama, Ehime, 790-0052, Japan.
Hisaaki TakahashiDivision of Pathophysiology, Faculty of Pharmaceutical Sciences, Hokuriku University, 1-1 Taiyogaoka, Kanazawa, 920-1180, Ishikawa, Japan.
Takeharu KuniedaDepartment of Neurosurgery, Ehime University School of Medicine, 454 Shitsukawa, Toon, Ehime, 791-0295, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAmide proton transfer (APT) imaging has been proposed as a technique to assess tumor metabolic activity. We have previously

methodsTwenty-six consecutive patients with GBMs were enrolled in this study. Among these 26 cases, 10 patients underwent

resultsThe most recent 14 cases underwent 3D FSE-APT. The 3D FSE-APT was visually almost equivalent to 2D SSFSE-APT and mean APT intensity (APT

conclusionsThe area of tumor invasion could be evaluated by 3D FSE-APT in a similar way to

Indexed as

Brain NeoplasmsGlioblastomaImaging, Three-DimensionalNeuronavigationPositron-Emission TomographyAdultAgedCarbon RadioisotopesFemaleHumansMaleMethionineMiddle Agedcarbon-11 methionineCarbon RadioisotopesMethionine3D fast spin echoAmide proton transferChemical exchange saturation transferGlioblastomaGlioma stem cellInvasion

Identifiers

PMID39969596
PMCPMC11839683

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.