Evidence map›Paper›PMID 39969560›Full record

SynthesisArchives of gynecology and obstetrics2025

Tinidazole vs metronidazole for the treatment of bacterial vaginosis: a systematic review and meta-analysis.

Milene Vitória Sampaio Sobral, Victor Gonçalves Soares, João Lucas de Magalhães Leal Moreira, Livia Kneipp Rodrigues, Hilária Saugo Faria, Clara de Andrade Pontual Peres, Lubna Al-Sharif, Maria Julia Gonzaga Pascoalin, Fernando Augusto Barreiros, Marina Ayabe Gomes de Moraes

Abstract readSystematic ReviewMeta-AnalysisComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Archives of gynecology and obstetrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Milene Vitória Sampaio SobralUniversity of Western Sao Paulo, Presidente Prudente, Brazil.ORCID 0009-0001-5754-6472
Victor Gonçalves SoaresFederal University of the Jequitinhonha and Mucuri Valleys, Diamantina, Brazil.
João Lucas de Magalhães Leal MoreiraState University of Feira de Santana, Feira de Santana, Brazil.
Livia Kneipp RodriguesFederal University of Minas Gerais, Belo Horizonte, Brazil.
Hilária Saugo FariaFederal University of Santa Maria, Santa Maria, Brazil.
Clara de Andrade Pontual PeresUniversity of Pernambuco, Recife, Brazil.
Lubna Al-SharifAn-Najah National, Nablus, Palestine.
Maria Julia Gonzaga PascoalinUniversity of Western Sao Paulo, Presidente Prudente, Brazil.
Fernando Augusto BarreirosDepartment of Gynecology and Obstetrics, University of Western Sao Paulo, Av. Washington Luiz, nº 874, Presidente Prudente, SP, Brazil.
Marina Ayabe Gomes de MoraesDepartment of Gynecology and Obstetrics, University of Western Sao Paulo, Av. Washington Luiz, nº 874, Presidente Prudente, SP, Brazil. marinaayabe@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionTinidazole shows potential as a first-line treatment for bacterial vaginosis (BV). However, its superiority to metronidazole remains uncertain. Therefore, this meta-analysis compares tinidazole versus metronidazole in patients with BV.

methodsWe systematically searched PubMed, Embase and Cochrane for studies comparing tinidazole and metronidazole in patients with BV. Statistical analyses were performed using R Studio 4.3.2. Heterogeneity was examined with the Cochran Q test and I

resultsFive randomized controlled trials and 1 prospective observational study, reporting data on 1,036 patients were included in this meta-analysis. Among them, 511 (49%) received tinidazole and 525 (51%) received metronidazole. Follow-up ranged from 1 to 6 weeks. There was no significant difference between groups for BV cure at the first follow-up appointment (RR 1.03; 95% CI 0.92 to 1.14; I

conclusionIn patients with BV, tinidazole and metronidazole exhibit similar efficacy and safety, with equivalent cure rates and incidence of adverse events.

Indexed as

Anti-Bacterial AgentsMetronidazoleTinidazoleVaginosis, BacterialFemaleHumansRandomized Controlled Trials as TopicTreatment OutcomeAnti-Bacterial AgentsMetronidazoleTinidazoleBacterial vaginosisMeta-analysisMetronidazoleTinidazole

Identifiers

PMID39969560
PMCPMC11890333

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.