Trial reportEuropean radiology2025
A randomised controlled trial comparing three clinical administration strategies in spectral detector CT pulmonary angiography with low contrast medium dose.
Trial report in European radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Vascular attenuation and volumetric lung iodine density in dual-layer spectral CT pulmonary angiography: a randomized controlled trial comparing three contrast doses.European radiology · 2026Trial
- Feasibility of reducing the contrast dose in infants and children with complex congenital heart disease using virtual monoenergetic images on dual-layer spectral detector computed tomography.Pediatric radiology · 2026Trial
- Increasing pulmonary artery visibility and diagnostic confidence with ultra-high resolution photon-counting detector CT pulmonary angiography.European radiology · 2026Article
- A personalized iodine delivery rate-based injection protocol in coronary angiography on photon-counting CT.European radiology · 2026Article
- Dual-energy CT pulmonary angiography using dual-flow mixture bolus tracking: potential for contrast medium and radiation exposure reduction.Insights into imaging · 2026Article
- Feasibility of Ultra-Dilute Iodine Contrast Agent in Dual-Layer Spectral CT for Pulmonary Artery ImagingCurrent medical imaging · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo compare vascular attenuation (VA) with three strategies for administering a low contrast medium (CM) dose in dual-layer spectral detector CT pulmonary angiography (CTPA).
methodsPatients were prospectively randomised into control- or one of two experimental groups. Control group patients received CM (350 mgI/mL) diluted 1:1 with saline. Experimental group B received CM (350 mgI/mL) with low flow. Experimental group C received CM with low concentration (140 mgI/mL). Virtual monoenergetic images at 40 and 55 kiloelectron Volt (keV) were reconstructed. Objective examination quality (OEQ) i.e., VA, noise, and signal-to-noise ratio, was measured and subjective examination quality (SEQ) was rated at three anatomical levels: in the pulmonary trunk (PT), the interlobar arteries and the posterior basal segmental arteries. PRIMARY OUTCOME: VA in PT at 40 keV. SECONDARY OUTCOMES: OEQ and SEQ across all anatomic levels.
resultsA total of 328 patients were randomised. 112 vs 115 and 101 were analysed in the control (A) vs experimental groups (B and C), respectively. There were no differences in VA in PT between the groups: A vs B (p = 0.96), B vs C (p = 0.14), and A vs C (p = 0.18). Group C showed higher VA across all anatomical levels. There were no differences in SEQ.
conclusionThere was no difference in the attenuation in the PT between the dilution-, low flow-, and low concentration groups. However, the low concentration group showed higher attenuation in the pulmonary arteries when all anatomical levels were assessed. KEY POINTS: Question Contrast medium reduction may be accomplished with dilution, low flow, or low concentration. However, the effect of the different strategies on vascular attenuation is unknown. Findings There was no difference in pulmonary trunk attenuation between the three strategies on spectral detector CT pulmonary angiography. Clinical relevance Low contrast medium dose spectral detector CT pulmonary angiography may be implemented with the administration strategy of the unit's own choice.
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