Evidence map›Paper›PMID 39969535›Full record

ReviewAnnals of hematology2025

Rare case of pure red cell aplasia secondary to smoldering multiple myeloma successfully treated with daratumumab - case report and review of the literature.

Malak Alharbi, Sawyer Bawek, Ian Lund, Sean T Glenn, Steven Green, Hamza Hassan, You-Wen Qian, Jens Hillengass

Abstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Annals of hematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Malak AlharbiDepartment of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, 14263, NY, USA. Alharbi.malaksaud@gmail.com.
Sawyer BawekDepartment of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, 14263, NY, USA.
Ian LundDepartment of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, 14263, NY, USA.
Sean T GlennDepartment of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY, USA.
Steven GreenDepartment of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, 14263, NY, USA.
Hamza HassanDepartment of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, 14263, NY, USA.
You-Wen QianDepartment of Pathology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Jens HillengassDepartment of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, 14263, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pure red cell aplasia (PRCA) is a rare hematological disorder characterized by erythroid hypoplasia and maturation arrest in the bone marrow. We present a case of acquired PRCA secondary to smoldering multiple myeloma (SMM), initially presenting as severe anemia requiring multiple blood transfusions. This case highlights the diagnostic dilemma at presentation as well as the therapeutic challenges in treating PRCA secondary to SMM. Here we discuss the appropriate workup and identify a potential option for managing these patients with subcutaenous daratumumab.

Indexed as

Antibodies, MonoclonalRed-Cell Aplasia, PureSmoldering Multiple MyelomaHumansAntibodies, MonoclonaldaratumumabCase reportDaratumumabPure red cell aplasiaSmoldering multiple myeloma

Identifiers

PMID39969535
PMCPMC12031742

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.