Evidence map›Paper›PMID 39969278›Full record

ArticleRadiology. Artificial intelligence2025

Automatic Quantification of Serial PET/CT Images for Pediatric Hodgkin Lymphoma Using a Longitudinally Aware Segmentation Network.

Xin Tie, Muheon Shin, Changhee Lee, Scott B Perlman, Zachary Huemann, Amy J Weisman, Sharon M Castellino, Kara M Kelly, Kathleen M McCarten, Adina L Alazraki and 3 more

Abstract read
In one paragraph

Article in Radiology. Artificial intelligence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. CNN-based detection of pediatric lymphoma on whole body [American journal of nuclear medicine and molecular imaging · 2026
    Article
  5. Article
  6. Deep Learning for Longitudinal Gross Tumor Volume Segmentation in MRI-Guided Adaptive Radiotherapy for Head and Neck Cancer.Head and Neck Tumor Segmentation for MR-Guided Applications : First MICCAI Challenge, HNTS-MRG 2024, held in conjunction with MICCAI 2024, Marrakesh, Morocco, October 17, 2024, proceedings · 2025
    Article
  7. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Xin TieDepartment of Radiology, University of Wisconsin School of Medicine and Public Health, 1111 Highland Ave, Madison, WI 53705.ORCID 0000-0003-3062-5995
Muheon ShinDepartment of Radiology, University of Wisconsin School of Medicine and Public Health, 1111 Highland Ave, Madison, WI 53705.
Changhee LeeDepartment of Radiology, University of Wisconsin School of Medicine and Public Health, 1111 Highland Ave, Madison, WI 53705.
Scott B PerlmanDepartment of Radiology, University of Wisconsin School of Medicine and Public Health, 1111 Highland Ave, Madison, WI 53705.ORCID 0000-0001-9744-7105
Zachary HuemannDepartment of Radiology, University of Wisconsin School of Medicine and Public Health, 1111 Highland Ave, Madison, WI 53705.ORCID 0000-0002-1472-243X
Amy J WeismanDepartment of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, Wis.
Sharon M CastellinoDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Ga.
Kara M KellyDepartment of Pediatric Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY.ORCID 0000-0003-1473-3937
Kathleen M McCartenDepartment of Pediatric Radiology, Imaging and Radiation Oncology, Core Rhode Island, Lincoln, RI.ORCID 0009-0002-2580-4171
Adina L AlazrakiDepartment of Radiology, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Ga.ORCID 0000-0003-1094-282X
Junjie HuDepartment of Biostatistics and Medical Informatics, University of Wisconsin School of Medicine and Public Health, Madison, Wis.ORCID 0000-0001-7137-7719
Steve Y ChoDepartment of Radiology, University of Wisconsin School of Medicine and Public Health, 1111 Highland Ave, Madison, WI 53705.ORCID 0000-0003-2724-7778
Tyler J BradshawDepartment of Radiology, University of Wisconsin School of Medicine and Public Health, 1111 Highland Ave, Madison, WI 53705.ORCID 0000-0001-9549-7002

Funding

NCTN BIQSFP ANBL1531 (NRT)U10CA180886 · NCI · PUBLIC HEALTH INSTITUTE · PI Douglas S. Hawkins · 2014 to 2026
$390.6M
COG FOREIGN ACCRUALU10CA098543 · NCI · NATIONAL CHILDHOOD CANCER FOUNDATION · PI ADAMSON, PETER C. · 2003 to 2013
$335.5M
COG SDMC - Statistics CoreU10CA180899 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TODD A ALONZO · 2014 to 2026
$132.8M
IROC: Enhancing local enrolling site radiological data capture capabilities for NCTN trialsU24CA180803 · NCI · AMERICAN COLLEGE OF RADIOLOGY · PI Thomas J. FitzGerald, MICHAEL V KNOPP · 2014 to 2026
$116.2M
Children's Oncology Group Statistics &Data Center GrantU10CA098413 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI DEVIDAS, MEENAKSHI · 2003 to 2013
$67.5M
QUALITY ASSURANCE REVIEW CENTER (QARC)U10CA029511 · NCI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI FITZGERALD, THOMAS J. · 1985 to 2013
$23.4M
Multimodal Learning for Contextually-Aware Longitudinal PET/CT image analysisR01EB033782 · NIBIB · UNIVERSITY OF WISCONSIN-MADISON · PI Tyler J Bradshaw · 2024 to 2026
$1.7M
Advancing novel therapeutics and translational science to close the survivorship gap in pediatric, adolescent and young adult (AYA) lymphomaR50CA285492 · NCI · EMORY UNIVERSITY · PI SHARON MARIE CASTELLINO · 2024 to 2026
$537k
Department of Defense W81XWH-22–1-0336NCI NIH HHS R50 CA285492NCI NIH HHS U10 CA029511NCI NIH HHS U10 CA098413NCI NIH HHS U10 CA098543NCI NIH HHS U10 CA180886NCI NIH HHS U10 CA180899NCI NIH HHS U24 CA180803NIBIB NIH HHS R01 EB033782
6 · The paper itself

Abstract

Purpose To develop a longitudinally aware segmentation network (LAS-Net) that can quantify serial PET/CT images for pediatric patients with Hodgkin lymphoma. Materials and Methods This retrospective study included baseline (PET1) and interim (PET2) PET/CT images from 297 pediatric patients enrolled in two Children's Oncology Group clinical trials (AHOD1331 and AHOD0831). The internal dataset included 200 patients (enrolled between March 2015 and August 2019; median age, 15.4 years [range, 5.6-22.0 years]; 107 male), and the external testing dataset included 97 patients (enrolled between December 2009 and January 2012; median age, 15.8 years [range, 5.2-21.4 years]; 59 male). LAS-Net incorporates longitudinal cross-attention, allowing relevant features from PET1 to inform the analysis of PET2. The model's lesion segmentation performance on PET1 images was evaluated using Dice coefficients, and lesion detection performance on PET2 images was evaluated using F1 scores. In addition, quantitative PET metrics, including metabolic tumor volume (MTV) and total lesion glycolysis (TLG) in PET1, as well as qPET and percentage difference between baseline and interim maximum standardized uptake value (∆SUV

Indexed as

Hodgkin DiseaseImage Interpretation, Computer-AssistedPositron Emission Tomography Computed TomographyAdolescentChildChild, PreschoolFemaleHumansMaleRetrospective StudiesYoung AdultConvolutional Neural Network (CNN)Deep LearningImage SegmentationLongitudinal AnalysisLymphomaPediatricsPET/CTQuantificationQuantitative PETSegmentationSupervised Learning

Identifiers

PMID39969278
PMCPMC12127956

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.