Evidence map›Paper›PMID 39969254›Full record

ReviewThe Journal of asthma : official journal of the Association for the Care of Asthma2025

Dual role of mucosal-associated invariant T cells (MAIT) in asthma.

M Asghar Pasha, Rawaa Alnabulsi, Aiden Wan, Russell J Hopp, Qi Yang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Journal of asthma : official journal of the Association for the Care of Asthma, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

M Asghar PashaDivision of Allergy and Immunology, Department of Medicine, Albany Medical College, Albany, NY, USA.
Rawaa AlnabulsiDivision of Allergy and Immunology, Department of Medicine, Albany Medical College, Albany, NY, USA.
Aiden WanDepartment of Pediatrics, Rutgers Institute for Translational Medicine and Science, Child Health Institute of New Jersey Rutgers, The State University of New Jersey, New Brunswick, NJ, USA.
Russell J HoppDepartment of Pediatrics, University of NE Medical Center and Children's Hospital and Medical Center, Omaha, NE, USA.
Qi YangDepartment of Pediatrics, Rutgers Institute for Translational Medicine and Science, Child Health Institute of New Jersey Rutgers, The State University of New Jersey, New Brunswick, NJ, USA.

Funding

Function and regulation of mucosal associated invariant T cells in the lungR01HL155021 · NHLBI · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI YANG, QI · 2021 to 2025
$2.8M
The development and function of aging-associate innate lymphoid cells in the choroid plexusRF1AG078459 · NIA · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI YANG, QI · 2023 to 2023
$1.9M
NHLBI NIH HHS R01 HL155021NIA NIH HHS RF1 AG078459
6 · The paper itself

Abstract

objectiveMucosal-associated invariant T cells (MAIT) are the predominant type of innate-like T cells in humans, and they represent a unique subset of microbiota-dependent invariant T cells. This Commentary reviews recent clinical studies and animal model research elucidating the multifaceted roles of MAIT cells in asthma.

methodA literature search was performed using PubMed and Google Scholar, and covered the period from 1960 to 2024. The search yielded more than 50 articles, and only essential original research articles and selected review articles were evaluated.

resultsRecent studies indicate that MAIT cell-derived effector molecules may play dual roles in asthma and allergic airway inflammation. While MAIT cells can produce the anti-inflammatory enzyme IL4I1 and the Th1 cytokine IFN-γ to repress allergic airway inflammation and airway hyperresponsiveness (AHR), they may also secrete IL-17. Which induces neutrophil infiltration and exacerbates AHR. In addition, some clinical studies from the literature search revealed a negative association between MAIT cell abundance and asthma. Regarding allergic airway inflammation, mouse model studies suggested that MAIT cells may play a protective role.

conclusionThese findings raise critical questions as to whether MAIT cells are friend or foe in asthma, and whether distinct subsets of MAIT cells play different roles in allergic airway inflammation. Further studies are needed to better understand the implication of MAIT cells in asthma pathogenesis, particularly in patients with severe asthma.

Indexed as

AsthmaMucosal-Associated Invariant T CellsAnimalsDisease Models, AnimalHumansMiceairway hyper-responsivenessAllergic airway inflammationcytokinesIL-17iNKTmicrobiotaneutrophilicsevere asthma

Identifiers

PMID39969254
PMCPMC12181059

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.