Evidence map›Paper›PMID 39969214›Full record

ArticleThe journal of pathology. Clinical research2025

Subtype-associated complexity and prognostic significance of the NLRP3 inflammasome landscape in pancreatic neoplasms.

Kristóf Németh, Eszter Mezei, Justína Vörös, Katalin Borka, Adrián Pesti, István Kenessey, András Kiss, András Budai

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In one paragraph

Article in The journal of pathology. Clinical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kristóf NémethDepartment of Pathology, Forensics and Insurance Medicine, Semmelweis University, Budapest, Hungary.ORCID 0000-0002-4953-7330
Eszter MezeiDepartment of Pathology, Forensics and Insurance Medicine, Semmelweis University, Budapest, Hungary.
Justína VörösDepartment of Pathology, Forensics and Insurance Medicine, Semmelweis University, Budapest, Hungary.ORCID 0000-0001-8178-3286
Katalin BorkaDepartment of Pathology, Forensics and Insurance Medicine, Semmelweis University, Budapest, Hungary.
Adrián PestiDepartment of Pathology, Forensics and Insurance Medicine, Semmelweis University, Budapest, Hungary.ORCID 0000-0001-6706-6221
István KenesseyDepartment of Pathology, Forensics and Insurance Medicine, Semmelweis University, Budapest, Hungary.ORCID 0000-0002-6963-8489
András KissDepartment of Pathology, Forensics and Insurance Medicine, Semmelweis University, Budapest, Hungary.
András BudaiDepartment of Pathology, Forensics and Insurance Medicine, Semmelweis University, Budapest, Hungary.ORCID 0000-0002-4634-2140

Funding

Nemzeti Kutatási Fejlesztési és Innovációs Hivatal K-128881
6 · The paper itself

Abstract

Intraductal papillary mucinous neoplasm (IPMN) can progress into malignant pancreatic cancer, posing challenges in accurately assessing the risk of malignancy. While the nucleotide-binding oligomerization domain (NOD)-like receptor pyrin domain containing 3 (NLRP3) inflammasome pathway's role in pancreatic ductal adenocarcinoma (PDAC) has been extensively studied, its implications in IPMN remain unexplored. This study aimed to investigate the prognostic significance of NLRP3 inflammasome-related proteins across IPMN subtypes and their associations with tumor characteristics, with a secondary focus on comparing expression patterns in IPMN and PDAC. A cohort of 187 patients (100 IPMN and 87 PDAC) underwent high-dimensional histopathological imaging using the multiplexed immunohistochemical consecutive staining on single slide method and a semi-automated image analysis workflow. Expression levels of NLRP3, apoptosis-associated speck-like protein containing a caspase-recruitment domain (ASC), caspase-1, interleukin-1 beta, interleukin-18 (IL-18), interleukin-1 receptor antagonist, and interleukin-18 binding protein (IL-18BP) were evaluated and compared between IPMN and PDAC samples. The relationships between protein expression and tumor characteristics were examined. Principal component analysis distinguished between intestinal and nonintestinal clusters based on NLRP3-associated proteins. Lower IL-18 expression was linked to the intestinal subtype, while higher caspase-1 was linked to the pancreatobiliary subtype. Elevated caspase-1 and ASC expression were associated with invasiveness in IPMN. No significant correlation was found between the examined proteins and later-stage tumor characteristics in invasive cases. The IL-18/IL-18BP ratio was an independent prognostic factor in invasive IPMN. Our findings highlight the prognostic significance of IL-18 and the IL-18/IL-18BP ratio in invasive IPMNs. These results point to a complex regulation of NLRP3 inflammasome proteins, especially effector cytokines, in pancreatic neoplasms, which are strongly linked to subtype and prognosis.

Indexed as

Biomarkers, TumorCarcinoma, Pancreatic DuctalInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinPancreatic Intraductal NeoplasmsPancreatic NeoplasmsAdultAgedAged, 80 and overFemaleHumansInterleukin-18MaleMiddle AgedPrognosisBiomarkers, TumorInflammasomesInterleukin-18NLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, humaninflammasomesinterleukin‐18IPMNneoplasm invasivenesspancreatic neoplasmsprognosis

Identifiers

PMID39969214
PMCPMC11837281

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.