Evidence map›Paper›PMID 39969179›Full record

ArticleInfection and immunity2025

Immunostimulatory effects of

Emily Helliwell, Isabella Rauch, Tim Nice, Justin Merritt, Jens Kreth

Abstract read
In one paragraph

Article in Infection and immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Journal of oral microbiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Emily HelliwellDivision of Biomaterial and Biomedical Sciences, School of Dentistry, Oregon Health & Science University, Portland, Oregon, USA.ORCID 0000-0001-6340-7260
Isabella RauchDepartment of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, Oregon, USA.ORCID 0000-0003-1897-5693
Tim NiceDepartment of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, Oregon, USA.
Justin MerrittDivision of Biomaterial and Biomedical Sciences, School of Dentistry, Oregon Health & Science University, Portland, Oregon, USA.ORCID 0000-0002-3464-0490
Jens KrethDivision of Biomaterial and Biomedical Sciences, School of Dentistry, Oregon Health & Science University, Portland, Oregon, USA.ORCID 0000-0002-8599-8310

Funding

Advancing studies of polymicrobial diseases via streptococcal geneticsR35DE028252 · NIDCR · OREGON HEALTH & SCIENCE UNIVERSITY · PI MERRITT, JUSTIN · 2018 to 2025
$7.8M
Innate immunity to enteric virus infection by IFN?-stimulated-gene expressionR01AI130055 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI Timothy J. Nice · 2017 to 2026
$4.2M
Pyruvate oxidase: a molecular determinant of commensalism among the oral microbiomeR01DE029492 · NIDCR · OREGON HEALTH & SCIENCE UNIVERSITY · PI KRETH, JENS · 2020 to 2024
$2.5M
The role of the tuft cell inflammasome in infectionR01AI167974 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI Isabella Rauch · 2022 to 2026
$1.9M
Streptococcal secretion of pyruvate - a novel antioxidant strategy in the oral biofilmR21DE029612 · NIDCR · OREGON HEALTH & SCIENCE UNIVERSITY · PI KRETH, JENS · 2020 to 2021
$424k
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI130055HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI167974HHS | NIH | National Institute of Dental and Craniofacial Research (NIDCR) DE028252HHS | NIH | National Institute of Dental and Craniofacial Research (NIDCR) DE029612, DE029492NIAID NIH HHS R01 AI130055NIAID NIH HHS R01 AI167974NIDCR NIH HHS R01 DE029492NIDCR NIH HHS R21 DE029612NIDCR NIH HHS R35 DE028252
6 · The paper itself

Abstract

The commensal

Indexed as

Epithelial CellsExtracellular VesiclesGingivaStreptococcus sanguisCytokinesHumansCytokinescommensalsimmune responseoral biofilmStreptococcus sanguinisvesicles

Identifiers

PMID39969179
PMCPMC11895462

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.