Evidence map›Paper›PMID 39969175›Full record

ArticlemBio2025

Microbiota does not influence tumor development in two models of heritable cancer.

Jessica Spring, Sandeep Gurbuxani, Tatyana Golovkina

Abstract read
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Jessica SpringCommittee on Microbiology, University of Chicago, Chicago, Illinois, USA.ORCID 0000-0002-7399-2819
Sandeep GurbuxaniDepartment of Pathology, University of Chicago, Chicago, Illinois, USA.
Tatyana GolovkinaCommittee on Microbiology, University of Chicago, Chicago, Illinois, USA.ORCID 0000-0002-2924-6747

Funding

VIRAL ONCOLOGY CORE FACILITYP30CA014599 · NCI · UNIVERSITY OF CHICAGO · PI KUNLE ODUNSI · 1985 to 2026
$122.1M
ULTRASTRUCTURE AND CYTOMORPHOLOGY COREP30DK042086 · NIDDK · UNIVERSITY OF CHICAGO · PI CHANG, EUGENE B · 1990 to 2025
$29.8M
Molecular And Cellular Biology Training ProgramT32GM007183 · NIGMS · UNIVERSITY OF CHICAGO · PI GLICK, BENJAMIN S, RICE, PHOEBE A · 1985 to 2021
$23.9M
Virally-induced tumorigenesis controlled by the microbiotaR01CA232882 · NCI · UNIVERSITY OF CHICAGO · PI Tatyana V Golovkina · 2019 to 2026
$3.5M
HHS | National Institutes of Health (NIH) CA232882HHS | National Institutes of Health (NIH) DK42086HHS | National Institutes of Health (NIH) GM007183HHS | National Institutes of Health (NIH) P30CA014599NCI NIH HHS P30 CA014599NCI NIH HHS R01 CA232882NIDDK NIH HHS P30 DK042086NIGMS NIH HHS T32 GM007183
6 · The paper itself

Abstract

Microbial impact on tumorigenesis of heritable cancers proximal to the gut is well-documented. Whether the microbiota influences cancers arising from inborn mutations at sites distal to the gut is undetermined. Using two models of heritable cancer, IMPORTANCE: The influence of the microbiome on the development of cancer is well-documented with many if not all published studies reporting either a positive or a negative impact. None of the published studies, however, presented data on the influence of the microbiome on the development of heritable cancer. We find that the microbiota has no influence on cancer development in two models of spontaneous cancers driven by germline

Indexed as

CarcinogenesisGastrointestinal MicrobiomeNeoplasmsAnimalsDisease Models, AnimalGerm-Free LifeMiceMice, TransgenicTumor Suppressor Protein p53Wnt1 ProteinTrp53 protein, mouseTumor Suppressor Protein p53Wnt1 ProteinWnt1 protein, mousecancergenetic predisposition to cancergut commensal bacteriaheritable cancermicrobiota

Identifiers

PMID39969175
PMCPMC11898629

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.