ArticleVeterinary medicine and science2025
Prevalence and Virulence Profiles of Klebsiella pneumoniae Isolated From Different Animals.
Article in Veterinary medicine and science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Eco-Geography Reverses Dominant AMR Reservoirs in Klebsiella pneumoniae: Integron-Rich Mobilomes and Cross-Niche Connectivity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Detection and Characterization of ESBL-Producing and Carbapenem-Resistant Klebsiella pneumoniae in Ornamental Birds and Their Surrounding Environments.MicrobiologyOpen · 2026Article
- Review
- Urinary Multidrug-ResistantMicroorganisms · 2025Article
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8 authors.
Funding
Abstract
backgroundKlebsiella pneumoniae liver abscess (KLA) is an invasive disease, and the occurrence of infection is related to its virulence factors and colonization of the host's gastrointestinal (GI) tract. Some animal-sourced isolates share virulence factors with human pathogens. However, the potential of K. pneumoniae as a zoonotic agent has not been confirmed in murine infection model.
objectivesTo identify the prevalence and virulence profiles of K. pneumoniae colonization in companion and wild animals and subsequently determine the pathogenicity of selected strains.
methodsForty-five K. pneumoniae isolates (45/302) were obtained from faeces of companion or wild animals. Virulence factors, gyrA polymerase chain reaction with the restriction fragment length polymorphism (PCR-RFLP) and pulsed field gel electrophoresis (PFGE) were detected and compared with our previous collection of 60 human pathogens. For KLA model and cytotoxicity test, three animal-sourced isolates, CHKP0009 (snake, K1, KpII), CHKP0021 (turtle, K2, pLVPK, KpI, cluster I) and CHKP1027 (dog, non-K1/K2, HV, KpI, cluster III), with similar genotype and/or phenotype to human pathogens were selected and evaluated for their virulence with human hypervirulent K. pneumoniae (hvKp) CG43S.
resultsThe prevalence of K. pneumoniae was higher in companion than wild animals. K. pneumoniae was primarily isolated from dogs, turtles and snakes. Some animal-sourced isolates carried virulence factors and revealed phylogenetic relatedness with human pathogens. In KLA model, BALB/c mice infected with snake isolate CHKP0009 and dog isolate CHKP1027 survived for 14 days but showed significant bacterial loads in the liver and spleen. Notably, the pet turtle isolate CHKP0021 presented comparable virulence with human hvKp CG43S and induced liver abscess formation. All three selected animal-sourced isolates could colonize in the GI tract and possess cytotoxic ability. These findings demonstrated pathogenicity of the animal K. pneumoniae isolates. In addition, the high prevalence of K. pneumoniae in companion animals and some isolates with virulence profiles suggested animal-sourced K. pneumoniae has the zoonotic potential to cause human disease.
conclusionAnimals are the natural hosts of zoonotic pathogens. Some animal-sourced K. pneumoniae isolates are not only pathogenic in vivo but also exhibit phylogenetic relatedness to human pathogens, suggesting the existence of a zoonotic risk for K. pneumoniae between these two populations.
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