ArticleJournal of veterinary internal medicine
Pre-clinical enteropathy in healthy soft-coated wheaten terriers.
Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- The Collaborative Collapse: Bile Acid Dysmetabolism as a Central Pathogenic Driver in Canine and Feline Multi-Systemic Disorders-From Mechanisms to Precision Therapeutics.Veterinary sciences · 2026Review
- Microbial Gene Profiling and Targeted Metabolomics in Fecal Samples of Dogs With Chronic Enteropathy With or Without Increased Dysbiosis Index.Journal of veterinary internal medicineArticle
- Pre-clinical enteropathy in healthy soft-coated wheaten terriers.Journal of veterinary internal medicineArticle
Corrections and comments
- Erratum issued
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSoft-coated wheaten terriers (SCWTs) have a predisposition to the development of protein-losing enteropathy (PLE). Early recognition of disease may improve morbidity and mortality in these and other at-risk dogs. Preclinical inflammatory bowel disease (IBD), characterized by increased intestinal permeability, immune dysregulation and inflammation, and changes to the gut microbial composition, or biochemical evidence of disease many years before development of clinical signs, has been proposed for people at risk for IBD. HYPOTHESIS/
objectivesDetermine if changes in fecal metabolites and intestinal permeability could be identified in SCWTs before development of clinical signs. We hypothesized that, in contrast to healthy non-SCWT dogs, healthy SCWT would have changes similar to those of dogs with PLE. ANIMALS: Twelve healthy SCWTs, 10 healthy non-SCWTs, and 8 PLE dogs.
methodsProspective study. Fecal calprotectin, targeted metabolites and unconjugated bile acids, intestinal permeability testing, and video capsule endoscopy were evaluated. Single-factor analysis of variance (ANOVA) was performed to evaluate fecal metabolites and bile acids for group differences. A repeated-measures mixed model ANOVA was performed for blood lactulose:galactose area under the curve (AUC).
resultsSignificant differences among groups were found for several fecal fatty acids and sterols. Healthy non-SCWT dogs, but not healthy SCWTs, were found to have significantly lower AUCs than PLE dogs (P = .04).
conclusionsHealthy SCWT dogs had changes in several biomarkers used to identify preclinical IBD in humans.
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