Evidence map›Paper›PMID 39968869›Full record

ArticleActa paediatrica (Oslo, Norway : 1992)2025

Poor Association Between Clinical Characteristics and Seropositivity in Children With Suspected Long COVID-A Single-Centre Study.

S Olsson-Åkefeldt, J Luthander, L Anmyr, L Villard, S Arnason, M K Kemani, E Wållgren, S Röstlund, M Tingborn, M Pettersson and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta paediatrica (Oslo, Norway : 1992), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

S Olsson-ÅkefeldtDepartment of Paediatric Infectious Diseases, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden.
J LuthanderDepartment of Paediatric Infectious Diseases, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden.ORCID 0000-0002-2428-2271
L AnmyrDepartment of Allied Health Professionals, Theme Women's Health and Allied Health Professionals, Karolinska University Hospital, Stockholm, Sweden.
L VillardDepartment of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
S ArnasonDepartment of Paediatric Infectious Diseases, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden.
M K KemaniDepartment of Allied Health Professionals, Theme Women's Health and Allied Health Professionals, Karolinska University Hospital, Stockholm, Sweden.
E WållgrenDepartment of Allied Health Professionals, Theme Women's Health and Allied Health Professionals, Karolinska University Hospital, Stockholm, Sweden.
S RöstlundDepartment of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
M TingbornDepartment of Allied Health Professionals, Theme Women's Health and Allied Health Professionals, Karolinska University Hospital, Stockholm, Sweden.
M PetterssonDepartment of Allied Health Professionals, Theme Women's Health and Allied Health Professionals, Karolinska University Hospital, Stockholm, Sweden.
E GeorgeDepartment of Paediatric Infectious Diseases, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden.
M Ryd-RinderDepartment of Paediatric Infectious Diseases, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden.
O HerttingDepartment of Paediatric Infectious Diseases, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden.ORCID 0000-0002-0813-7998

Funding

Henry and Ella Margareta Stahl FoundationThe Pediatric Research Foundation at Astrid Lindgren Children's Hospital
6 · The paper itself

Abstract

aimWe aimed to compare characteristics and clinical presentation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody positive or negative children attending a specialist outpatient clinic for suspected paediatric long COVID.

methodsA cross-sectional study was conducted of 113 children and adolescents enrolled between 1 December 2020 to 14 September 2021 in a multidisciplinary programme. Clinical and epidemiological data were collected with standardised interviews and laboratory tests including SARS-CoV-2 spike antibody measurement.

resultsA serological link to SARS-CoV-2 infection was found in 52%. Most patients (94.7%) reported several symptoms. Fatigue, post-exertional malaise, dizziness, nausea, headache, and concentration difficulties were the most common. Seronegative children had a higher number of individual symptoms. School absence and drop-out from leisure activities was substantial in both groups with higher numbers for the seronegative group. Self-reported health was low in both groups.

conclusionChildren attending a specialist paediatric long COVID clinic experienced multiple symptoms and poor self-reported health. The symptomatology was similar regardless of serological status, implying multifactorial causes. A multidisciplinary assessment of this cohort was essential considering the broad spectrum of symptoms displayed and their substantial impact on everyday functioning.

Indexed as

COVID-19AdolescentAntibodies, ViralChildChild, PreschoolCross-Sectional StudiesFemaleHumansMaleSARS-CoV-2Antibodies, ViralchildrenCOVID‐19long COVIDlong‐term symptomsSARS‐CoV‐2

Identifiers

PMID39968869
PMCPMC12258088

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.