Evidence map›Paper›PMID 39968856›Full record

ArticleThe Journal of physiology2025

Systolic and diastolic dysfunction is exacerbated by age and spinal cord injury in male and female mice with central nervous system serotonin deficiency.

Qingchao Qiu, Dragana Komnenov, Mirabela Hali, Charles S Chung, Patrick J Mueller, Noreen F Rossi, Donald M Kuhn, Jason H Mateika

Abstract read
In one paragraph

Article in The Journal of physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qingchao QiuJohn D. Dingell Veterans Affairs Medical Center, Detroit, MI, USA.ORCID 0000-0002-3856-9433
Dragana KomnenovJohn D. Dingell Veterans Affairs Medical Center, Detroit, MI, USA.
Mirabela HaliJohn D. Dingell Veterans Affairs Medical Center, Detroit, MI, USA.
Charles S ChungDepartment of Physiology, Wayne State University School of Medicine, Detroit, MI, USA.ORCID 0000-0001-9180-3236
Patrick J MuellerDepartment of Physiology, Wayne State University School of Medicine, Detroit, MI, USA.
Noreen F RossiJohn D. Dingell Veterans Affairs Medical Center, Detroit, MI, USA.ORCID 0000-0002-5886-427X
Donald M KuhnJohn D. Dingell Veterans Affairs Medical Center, Detroit, MI, USA.ORCID 0000-0001-6453-3568
Jason H MateikaJohn D. Dingell Veterans Affairs Medical Center, Detroit, MI, USA.

Funding

Mild intermittent hypoxia and CPAP: A multi-pronged approach to treat sleep apnea in intact and spinal cord injured humansR01HL142757 · NHLBI · WAYNE STATE UNIVERSITY · PI MATEIKA, JASON H. · 2019 to 2022
$1.5M
BLRD VA I01 BX003946BLRD VA I01 BX006288CSRD VA IK6 CX002287NHLBI NIH HHS R01 HL142757RRD VA IK1 RX003985
6 · The paper itself

Abstract

The present study was designed to explore whether the depletion of serotonin (5-HT) in the central nervous system (CNS

Indexed as

AgingSerotoninSpinal Cord InjuriesAnimalsDiastoleFemaleMaleMiceMice, Inbred C57BLMice, KnockoutSympathetic Nervous SystemSystoleTryptophan HydroxylaseSerotoninTph2 protein, mouseTryptophan Hydroxylaseburst heightburst incidenceechocardiogramheart failurelumbar sympathetic nerve activitymiceserotonin

Identifiers

PMID39968856
PMCPMC11908478

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.