Evidence map›Paper›PMID 39968792›Full record

ArticleJournal of the American Heart Association2025

Temporal Trends in Stroke Management and Outcomes Between 2011 and 2020 in South Korea: Results From a Nationwide Multicenter Registry.

Tai Hwan Park, Keun-Sik Hong, Yong-Jin Cho, Wi-Sun Ryu, Dong-Eog Kim, Man-Seok Park, Kang-Ho Choi, Joon-Tae Kim, Jihoon Kang, Beom-Joon Kim and 26 more

Abstract readMulticenter Study
In one paragraph

Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

36 authors.

Tai Hwan ParkDepartment of Neurology Seoul Medical Center Seoul Korea.ORCID 0000-0002-5148-1663
Keun-Sik HongDepartment of Neurology Ilsan Paik Hospital, Inje University Goyang Korea.ORCID 0000-0002-4684-6111
Yong-Jin ChoDepartment of Neurology Ilsan Paik Hospital, Inje University Goyang Korea.ORCID 0000-0001-6965-0771
Wi-Sun RyuDepartment of Neurology Dongguk University Ilsan Hospital Goyang Korea.ORCID 0000-0002-2823-5253
Dong-Eog KimDepartment of Neurology Dongguk University Ilsan Hospital Goyang Korea.
Man-Seok ParkDepartment of Neurology Chonnam National University Hospital Gwangju Korea.ORCID 0000-0002-0637-5394
Kang-Ho ChoiDepartment of Neurology Chonnam National University Hospital Gwangju Korea.ORCID 0000-0001-8851-2104
Joon-Tae KimDepartment of Neurology Chonnam National University Hospital Gwangju Korea.ORCID 0000-0003-4028-8339
Jihoon KangDepartment of Neurology, Cerebrovascular Center Seoul National University Bundang Hospital Seongnam Korea.ORCID 0000-0001-5715-6610
Beom-Joon KimDepartment of Neurology, Cerebrovascular Center Seoul National University Bundang Hospital Seongnam Korea.ORCID 0000-0002-2719-3012
Moon-Ku HanDepartment of Neurology, Cerebrovascular Center Seoul National University Bundang Hospital Seongnam Korea.ORCID 0000-0003-0166-387X
Jun LeeDepartment of Neurology Yeungnam University Hospital Daegu Korea.ORCID 0000-0001-8643-0797
Jae-Kwan ChaDepartment of Neurology Dong-A University Hospital Busan Korea.ORCID 0000-0002-1049-5196
Dae-Hyun KimDepartment of Neurology Dong-A University Hospital Busan Korea.ORCID 0000-0001-9761-7792
Jae Guk KimDepartment of Neurology Eulji University Hospital, Eulji University Daejeon Korea.ORCID 0000-0003-1418-0033
Soo Joo LeeDepartment of Neurology Eulji University Hospital, Eulji University Daejeon Korea.ORCID 0000-0001-8622-7000
Jee-Hyun KwonDepartment of Neurology Ulsan University College of Medicine Ulsan Korea.ORCID 0000-0002-5894-3146
Wook-Joo KimDepartment of Neurology Ulsan University College of Medicine Ulsan Korea.ORCID 0000-0001-5290-0623
Dong-Ick ShinDepartment of Neurology Chungbuk National University Hospital Cheongju Korea.ORCID 0000-0001-5770-0268
Kyu Sun YumDepartment of Neurology Chungbuk National University Hospital Cheongju Korea.ORCID 0000-0001-9815-7652
Sung Il SohnDepartment of Neurology Keimyung University Dongsan Medical Center Daegu Korea.ORCID 0000-0002-6900-1242
Jeong-Ho HongDepartment of Neurology Keimyung University Dongsan Medical Center Daegu Korea.ORCID 0000-0002-8235-9855
Jay Chol ChoiDepartment of Neurology Jeju National University Hospital, Jeju National University School of Medicine Jeju Korea.ORCID 0000-0002-3550-2196
Byung-Chul LeeDepartment of Neurology Hallym University Sacred Heart Hospital Anyang Korea.ORCID 0000-0002-3885-981X
Kyung-Ho YuDepartment of Neurology Hallym University Sacred Heart Hospital Anyang Korea.ORCID 0000-0002-8997-5626
Mi-Sun OhDepartment of Neurology Hallym University Sacred Heart Hospital Anyang Korea.ORCID 0000-0002-6741-0464
Jong-Moo ParkDepartment of Neurology Uijeongbu Eulji Medical Center, Eulji University Uijenongbu Korea.ORCID 0000-0002-4199-3024
Kyusik KangDepartment of Neurology Nowon Eulji Medical Center, Eulji University School of Medicine Seoul Korea.ORCID 0000-0002-4021-4439
Kyungbok LeeDepartment of Neurology Soonchunhyang University Hospital Seoul Korea.ORCID 0000-0003-2663-7483
Sang-Hwa LeeDepartment of Neurology Hallym University Chuncheon Sacred Heart Hospital Chuncheon-si Gangwon-do Korea.
Hae-Bong JeongDepartment of Neurology Chung-Ang University Hospital Seoul Korea.ORCID 0000-0002-4937-288X
Kwang-Yeol ParkDepartment of Neurology Chung-Ang University Hospital Seoul Korea.ORCID 0000-0003-4570-3538
Ji Sung LeeAsan Medical Center Clinical Research Center Seoul Korea.ORCID 0000-0001-8194-3462
Juneyoung LeeDepartment of Biostatistics Korea University College of Medicine Seoul Korea.ORCID 0000-0001-8073-9304
Philip B GorelickDavee Department of Neurology Northwestern University Feinberg School of Medicine Chicago IL USA.ORCID 0000-0002-1181-614X
Hee-Joon BaeDepartment of Neurology, Cerebrovascular Center Seoul National University Bundang Hospital Seongnam Korea.ORCID 0000-0003-0051-1997

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study aims to evaluate temporal trends of advanced treatments and related clinical outcomes of ischemic stroke through a decade-long trend analysis, using data from a comprehensive, national, multicenter registry. We also seek to identify areas in need of improvement. METHODS AND

resultsThis analysis involved patients with ischemic stroke or transient ischemic attack registered prospectively in the CRCS-K-NIH (Clinical Research Center for Stroke in Korea-National Institute of Health) registry between 2011 and 2020. We examined temporal trends in risk factors, pathogenetic subtypes, acute management strategies, and outcomes for up to 1 year following a stroke. Generalized linear mixed models were used to account for center clustering. The average age of 77 662 patients increased 2.2 years in men and 2.4 years in women over the 10-year follow-up. Notably, in-hospital neurological deterioration, 3-month and 1-year mortality rate, and cumulative incidence of recurrent stroke within 1-year decreased over time after adjustments for age, sex, and initial stroke severity (

conclusionsThis study points to a reduction in death and risk of recurrent stroke over the past decade, paralleling enhancement in acute and preventive stroke management. Nevertheless, the decline in the use of intravenous thrombolysis and the lack of improvement in functional outcomes following stroke are concerning trends that warrant thorough investigation.

Indexed as

Endovascular ProceduresIschemic Attack, TransientIschemic StrokeStrokeThrombectomyThrombolytic TherapyAgedAged, 80 and overFemaleHumansIncidenceMaleMiddle AgedPlatelet Aggregation InhibitorsRegistriesRepublic of KoreaPlatelet Aggregation Inhibitorsadvanced treatmentsclinical outcomesischemic stroketemporal trends

Identifiers

PMID39968792
PMCPMC12132717

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.