Evidence map›Paper›PMID 39968775›Full record

ArticleJournal of the American Heart Association2025

Intravenous Thrombolysis in Cervical Artery Dissection-Related Stroke: A Nationwide Study.

Liqi Shu, Elizabeth Lee, Thalia S Field, Xiaofan Guo, Nils Henninger, Zafer Keser, Muhib Khan, Eva A Mistry, Thanh N Nguyen, James E Siegler and 5 more

Abstract read
In one paragraph

Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Liqi ShuDepartment of Neurology The Warren Alpert Medical School of Brown University Providence RI.ORCID 0000-0002-9784-8475
Elizabeth LeeDepartment of Neurology The Warren Alpert Medical School of Brown University Providence RI.ORCID 0009-0007-2954-7092
Thalia S FieldVancouver Stroke Program, Division of Neurology University of British Columbia Vancouver British Columbia Canada.ORCID 0000-0002-1176-0633
Xiaofan GuoDepartment of Neurology UPMC Stroke Institute Pittsburgh PA.ORCID 0000-0002-7220-5094
Nils HenningerDepartment of Neurology University of Massachusetts Chan Medical School Worcester MA.ORCID 0000-0002-3883-5623
Zafer KeserDepartment of Neurology Mayo Clinic Rochester MN.ORCID 0000-0001-6415-0874
Muhib KhanDepartment of Neurology Mayo Clinic Rochester MN.ORCID 0000-0001-6329-8703
Eva A MistryDepartment of Neurology and Rehabilitation Medicine University of Cincinnati Cincinnati OH.ORCID 0000-0002-7426-3650
Thanh N NguyenDepartment of Neurology Boston Medical Center Boston MA.ORCID 0000-0002-2810-1685
James E SieglerDepartment of Neurology University of Chicago Chicago IL.ORCID 0000-0003-0287-3967
Lukas StreleckyDepartment of Neurology The Warren Alpert Medical School of Brown University Providence RI.ORCID 0009-0006-7089-4507
Daniel M MandelDepartment of Neurology University of Miami Miller School of Medicine Miami FL.ORCID 0000-0002-9484-4698
Christoph StretzDepartment of Neurology The Warren Alpert Medical School of Brown University Providence RI.ORCID 0000-0003-4125-4077
Karen L FurieDepartment of Neurology The Warren Alpert Medical School of Brown University Providence RI.ORCID 0000-0003-0065-3784
Shadi YaghiDepartment of Neurology The Warren Alpert Medical School of Brown University Providence RI.ORCID 0000-0003-0031-1004

Funding

Statistical Methods to Jointly Model Multiple Pain Outcome MeasuresU24NS113844 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI TROXEL, ANDREA B, YU, CHANG · 2019 to 2024
$25.9M
Southern New England Partnership In Stroke Research, Innovation and Treatment (SPIRIT)U24NS107215 · NINDS · YALE UNIVERSITY · PI MARK Jay ALBERTS, Karen L Furie · 2018 to 2026
$3.0M
Cardioembolism as a Mechanism of Central Retinal Artery OcclusionK23HL161426 · NHLBI · DUKE UNIVERSITY · PI Brian Mac Grory · 2022 to 2026
$951k
Kinetic analysis of acute stroke secondary prevention trials: Insights from combined datasets guiding future trial designR61NS135583 · NINDS · UNIVERSITY OF CHICAGO · PI BRORSON, JAMES R. · 2024 to 2025
$762k
Improving patient care in severe acute brain injury: a web/mobile/tablet-based communication and decision support tool for clinicians and families in the neuro-ICUR21NR020231 · NINR · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI HENNINGER, NILS, MUEHLSCHLEGEL, SUSANNE · 2022 to 2023
$461k
Role of Sarm1 in TBI-accentuated C9orf72 Frontotemporal DementiaR21NS131756 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI HENNINGER, NILS · 2023 to 2024
$461k
PREDOCTORAL FELLOWSHIPS FOR STUDENTS WITH DISABILITIESF31DC004784 · NIDCD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WRISLEY, DIANE M · 2000 to 2001
$56k
NHLBI NIH HHS K23 HL161426NIDCD NIH HHS F31 DC004784NINDS NIH HHS R21 NS131756NINDS NIH HHS R61 NS135583NINDS NIH HHS U24 NS107215NINDS NIH HHS U24 NS113844NINR NIH HHS R21 NR020231
6 · The paper itself

Abstract

backgroundAlthough intravenous thrombolysis (IVT) is safe and effective in populations with general stroke, its impact on cervical artery dissection-related acute ischemic stroke (CeAD-AIS) remains unclear. This retrospective study used the National Inpatient Sample to compare outcomes in patients with CeAD-AIS treated with and without IVT.

methodsWe included adult patients with concurrent CeAD and AIS diagnoses (

resultsBetween 2016 and 2019, 1360 (12.1%) of 11 285 patients with CeAD-AIS received IVT. IVT-treated patients had higher median National Institutes of Health Stroke Scale scores (median [interquartile range], 8 [4-17] versus 3 [1-11];

conclusionsIVT improves the likelihood of home discharge in patients with CeAD-AIS without increasing the risk of inpatient death or intracerebral hemorrhage.

Indexed as

Carotid Artery, Internal, DissectionFibrinolytic AgentsIschemic StrokeThrombolytic TherapyAdministration, IntravenousAgedFemaleHospital MortalityHumansMaleMiddle AgedRetrospective StudiesTreatment OutcomeUnited StatesFibrinolytic Agentscervical dissectionintravenous thrombolysisstroke

Identifiers

PMID39968775
PMCPMC12132603

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.