SynthesisInternational forum of allergy & rhinology2025
Content Validity of Patient-Reported Outcome Measures Developed for Assessing Disease-Specific Quality of Life in Children With Sinonasal Disease: A Systematic Review.
Synthesis in International forum of allergy & rhinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Psychometric properties of health-related quality of life assessment instruments in idiopathic pulmonary fibrosis: a systematic review applying COSMIN methodology.Health and quality of life outcomes · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesPaediatric sinonasal disease is prevalent worldwide, giving rise to substantial healthcare costs and morbidity. However, there is a lack of sinus-specific patient-reported outcome measures (PROMs) tailored for children. This study aimed to evaluate existing PROMs against established validation criteria to determine whether a paediatric-specific, validated instrument for assessing sinonasal disease currently exists.
methodsMedline (Ovid), Embase (Ovid), Emcare (Ovid), and the Cochrane Library were searched from inception to January 2024. Eligibility was restricted to PROM development or content validity studies conducted in all children with sinonasal disease. Content validity was assessed using the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) methodology, with evidence graded using a modified GRADE approach.
resultsFive PROMs were identified: two for acute sinus disease (Sinus-5 [S5] and Paediatric Rhinosinusitis Symptom Scale [PRSS]), two for general rhinosinusitis (Sinonasal-5 [SN-5] and Modified Sinonasal Outcome Test-20 Young Persons Questionnaire [MSYPQ]) and one specific to primary ciliary dyskinesia (PCD; PCD quality of life [PCD-QoL]). No content validity studies were included in the final analysis. The development of the S5, PRSS, SN-5 and MSYPQ was found to be inadequate, supported by low-quality evidence, whereas the PCD-QoL stood out as a well-developed tool created using established evidence-based guidelines.
conclusionsAmong the assessed tools, only the PCD-QoL met standards for use in clinical trials, highlighting the need for a dedicated instrument to track disease status and QoL in otherwise healthy children with sinonasal disease.
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Registered trials
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