Evidence map›Paper›PMID 39968526›Full record

ArticleNAR cancer2025

Caroline D Doherty, Brandon A Wilbanks, Sonia Jain, Keenan S Pearson, Katie K Bakken, Danielle M Burgenske, Nay Won Lett, Jann N Sarkaria, Louis J Maher

Abstract read
In one paragraph

Article in NAR cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Aptamer targeting proprotein convertase subtilisin/kexin type 9:Research in pharmaceutical sciences · 2026
    Article
  2. NAR cancer · 2026
    Article
  3. Article
  4. Review
  5. Advantages, applications, and future directions ofMolecular therapy. Nucleic acids · 2025
    Review
  6. Methods for cell- and tissue-specific DNA aptamer selection.Molecular therapy. Methods & clinical development · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Caroline D DohertyD epartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic Graduate School of Biomedical Sciences, Rochester, MN 55905, United States.
Brandon A WilbanksDepartment of Biochemistry and Molecular Biology, Mayo Clinic Graduate School of Biomedical Sciences, Rochester, MN 55905, United States.
Sonia JainDepartment of Radiation Oncology, Mayo Clinic, Rochester, MN 55905, United States.
Keenan S PearsonDepartment of Biochemistry and Molecular Biology, Mayo Clinic Graduate School of Biomedical Sciences, Rochester, MN 55905, United States.
Katie K BakkenDepartment of Radiation Oncology, Mayo Clinic, Rochester, MN 55905, United States.
Danielle M BurgenskeDepartment of Radiation Oncology, Mayo Clinic, Rochester, MN 55905, United States.
Nay Won LettDepartment of Biochemistry and Molecular Biology, Mayo Clinic Graduate School of Biomedical Sciences, Rochester, MN 55905, United States.
Jann N SarkariaDepartment of Biochemistry and Molecular Biology, Mayo Clinic Graduate School of Biomedical Sciences, Rochester, MN 55905, United States.
Louis J MaherDepartment of Biochemistry and Molecular Biology, Mayo Clinic Graduate School of Biomedical Sciences, Rochester, MN 55905, United States.ORCID 0000-0002-5043-6422

Funding

Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
In vivo SELEX strategies to identify potent aptamer-drug conjugates for glioblastomaR61NS128071 · NINDS · MAYO CLINIC ROCHESTER · PI MAHER, LOUIS JAMES, SARKARIA, JANN N. · 2023 to 2024
$801k
NCATS NIH HHS UL1 TR000135NINDS NIH HHS R61 NS128071
6 · The paper itself

Abstract

Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor of adults. Current therapeutic options yield dismal prognoses that have remained essentially unchanged over nearly two decades. Diffuse growth patterns, high intratumoral heterogeneity, and variable blood-brain barrier integrity limit treatment efficacy, creating challenges that rational small molecule design has not overcome. Antibody-drug conjugates have shown some promise, leading us to hypothesize that smaller folded DNA aptamers, developed

Indexed as

Aptamers, NucleotideBrain NeoplasmsGlioblastomaAnimalsCell Line, TumorHumansMiceSELEX Aptamer TechniqueXenograft Model Antitumor AssaysAptamers, Nucleotide

Identifiers

PMID39968526
PMCPMC11833697

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.