ArticleMedical journal of the Islamic Republic of Iran2024
The Effect of Some Micronutrients Multi-Supplementation on Thyroid Function, Metabolic Features and Quality of Life in Patients Treating With Levothyroxine and Vitamin D: A Double-blind, Randomized Controlled Trial.
Article in Medical journal of the Islamic Republic of Iran, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: It has been reported that reducing inflammatory damage and providing essential nutrients can improve thyroid function. Although sufficient clinical evidence does not support the routine prescription of nutritional supplements except for vitamin D therapy, as part of hypothyroidism treatment. We aimed to investigate the effects of supplementation with certain micronutrients known as essential for normal thyroid function on thyroid function, metabolic manifestations, and quality of life in patients with hypothyroidism. Methods: In the current randomized controlled trial, we randomly assigned 104 patients with hypothyroidism receiving levothyroxine and vitamin D to either supplementation with 200 µg selenium, 15 mg zinc, 250 mg magnesium, 2500 IU vitamin A, 120 mg vitamin C, and 100 IU vitamin E per day (LT4VDS group) or placebos (LT4VDP group) for 8 weeks. Serum thyroid-stimulating hormone (TSH), free thyroxine (fT4), anti-thyroid peroxidase antibody (TPO-Ab), triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL-c), high-density lipoprotein (HDL-c), fasting blood sugar (FBS), fasting insulin, homeostatic model assessment for insulin resistance (HOMA-IR), C-reactive protein (CRP), as well as blood pressure, and anthropometric values, were measured before and after intervention. The 36-item short-form survey, the International Physical Activity Questionnaire, and 2 food recalls were completed. Thyroid function test, metabolic factors, and quality of life indices were compared between the 2 groups after the intervention, using analysis of covariance tests, with robust standard errors and intention to treat analysis, "multiple imputation method," adjusted for covariates. Results: In the LT4VDP group, higher postintervention values of FBS (98.5 [85.7, 106.5] in LT4VDP group vs 89 [82.5, 95.7] in LT4VDS group; Conclusion: An 8-week supplementation with the nutrients above may affect insulin resistance and quality of life in patients with hypothyroidism; additional clinical trials are recommended.
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