ArticleFrontiers in neurology2025
Secondary bilateral synchronization of interictal EEG discharges in focal epilepsy: prevalence and associated factors.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Epilepsy is commonly categorized based on etiology, treatment, and prognosis. Misclassification can occur due to the presence of interictal secondary bilateral synchronization (SBS) discharges seen on an electroencephalogram (EEG), misleading the classification process. Objective: To examine the prevalence of interictal SBS discharges in patients with focal epilepsy and to identify predictors of these discharges. Design: Retrospective analysis of patients who underwent long-term video EEG monitoring (LTVEM) from August 2001 to May 2014. Methods: We included patients with focal epilepsy. The patients were divided into two groups based on whether or not they had SBS discharges. Results: We found 1,017 patients who underwent LTVEM. Of the 221 patients included in the final analysis, 36 (16%) exhibited SBS discharges. Patients in the SBS group were younger and had an earlier onset age of epilepsy. They also had higher rates of unclear seizure onset zone and focal to bilateral tonic-clonic seizures. In the binary logistic regression analysis, young onset age of epilepsy was the only significant factor. Conclusion: The prevalence of SBS discharges in focal epilepsy is relatively high (16%), emphasizing the importance of cautious interpretation of interictal EEG in epilepsy classification. Young age of disease onset is associated with higher rates of SBS.
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