ArticleCureus2025
Evaluating the Anxiolytic Efficacy of Oral Alprazolam in Modulating Vital Parameters During Minor Oral Surgical Procedures: A Quasi-experimental Study.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Preoperative Anxiolysis in Surgical Care Without Sedation or General Anesthesia: A Systematic Review.Dentistry journal · 2026Review
- Melatonin and Alprazolam as Anxiolytic Agents in Minor Oral Surgical Procedures - A Comparative Study.Annals of maxillofacial surgeryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionDental anxiety is a prevalent issue among patients undergoing minor oral surgical procedures such as extractions, biopsies, and implant placement. This study aimed to evaluate the impact of oral alprazolam as a premedicative anxiolytic agent on vital parameters, including pulse rate (PR), systolic and diastolic blood pressure (SBP and DBP, respectively), respiratory rate (RR), and oxygen saturation (SpO2), in patients undergoing minor oral surgeries. MATERIALS AND
methodsA quasi-experimental study was conducted on patients aged 18-45 years who required minor oral surgical procedures under local anesthesia (LA) and were divided into two groups based on the Dental Anxiety Scale (DAS) scores. Group 1 (anxious; DAS score > 11) received 0.25 mg oral alprazolam 30 minutes pre-operatively, while Group 2 (non-anxious/mildly anxious; DAS score < 10) underwent surgery without alprazolam. Vital parameters were recorded at three intervals: preoperatively (T0), intraoperatively (15 minutes after starting surgery; T1), and postoperatively (30 minutes after surgery; T2). Statistical analyses included independent t-tests and logistic regression analyses to evaluate differences and associations.
resultsA significant reduction in PR, RR, and SBP was observed in Group 1 across all intervals, compared to Group 2, indicating the effectiveness of alprazolam in stabilizing physiological responses. Postoperative SpO₂ levels remained unaffected in both groups, ensuring patient safety. Logistic regression analysis revealed that elevated preoperative PR, SBP, and RR were significant predictors of anxiety, highlighting their role in identifying candidates for anxiolytic premedication.
conclusionPremedication with 0.25 mg oral alprazolam effectively alleviated anxiety and stabilized vital parameters during minor oral surgeries, thereby enhancing patient comfort and procedural efficacy. These findings emphasize the importance of incorporating anxiolytic strategies into dental practice to optimize patient care and surgical outcomes. Future studies should explore different doses and broader populations to refine the anxiolytic interventions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.