ArticleInnovation in aging2025
Adult Socioeconomic Position Mediates the Association Between Childhood Socioeconomic Position and Later-Life Frailty Trajectory: A Nationally Representative Cohort Study.
Article in Innovation in aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Interplay between frailty and cardiometabolic disorders: from pathophysiology to clinical implications.Cardiovascular diabetology · 2025Pooled it
- Socio-economic position and healthy ageing across the life course: a systematic review of longitudinal studies.GeroScience · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Objectives: Early-life risk factors influence the aging process in the short term and shape its trajectory in the long term. We aim to (1) explore the association between childhood socioeconomic position (cSEP) and frailty trajectories and (2) test whether adult socioeconomic position (aSEP) mediates the association between cSEP and frailty trajectories. Research Design and Methods: We analyzed 4 waves of the China Health and Retirement Longitudinal Study data. The frailty index was estimated based on the number of individual deficits across 40 indicator variables. Principal component analysis was used to generate cSEP and aSEP. Group-based trajectory models were used to identify the patterns of frailty trajectories over time. Causal mediation analysis was conducted to determine whether the aSEP mediated the association between cSEP and frailty trajectories. Results: We identified 3 distinct trajectories of frailty progression. Low cSEP was significantly associated with "High and increasing frailty trajectory" (odds ratio [OR] = 1.76, 95% confidence intervals [95% CI]: 1.38-2.23; adjusted OR = 1.55, 95% CI: 1.22-1.97). About 30% of the cSEP effect on rising frailty trajectory was mediated through the aSEP, and there is a significant gender disparity in the mediating effect of aSEP (18% among men and 51% among women, respectively). Discussion and Implications: Our findings suggest that policies that initially benefit children will yield well-being benefits as they reach adulthood. Promoting ongoing cSEP advantages increases the likelihood of delaying frailty progression in later life. This study underscores the critical importance of addressing social determinants of health throughout one's life course to foster healthy aging and diminish health disparities in later stages of life.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.