Evidence map›Paper›PMID 39968288›Full record

ArticleBeilstein journal of organic chemistry2025

Synthesis, characterization, antimicrobial, cytotoxic and carbonic anhydrase inhibition activities of multifunctional pyrazolo-1,2-benzothiazine acetamides.

Ayesha Saeed, Shahana Ehsan, Muhammad Zia-Ur-Rehman, Erin M Marshall, Sandra Loesgen, Abdus Saleem, Simone Giovannuzzi, Claudiu T Supuran

Abstract read
In one paragraph

Article in Beilstein journal of organic chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ayesha SaeedDepartment of Chemistry, Lahore College for Women University, Jail Road, Lahore 54000, Pakistan.ORCID https://orcid.org/0009-0005-5605-9946
Shahana EhsanDepartment of Chemistry, Lahore College for Women University, Jail Road, Lahore 54000, Pakistan.ORCID https://orcid.org/0009-0006-4942-7744
Muhammad Zia-Ur-RehmanApplied Chemistry Research Centre, PCSIR Laboratories Complex, Lahore 54600, Pakistan.ORCID https://orcid.org/0000-0001-6208-4527
Erin M MarshallWhitney Laboratory for Marine Bioscience, University of Florida, St. Augustine, Florida 32080, USA.ORCID https://orcid.org/0009-0000-0681-0600
Sandra LoesgenWhitney Laboratory for Marine Bioscience, University of Florida, St. Augustine, Florida 32080, USA.ORCID https://orcid.org/0000-0003-1090-564X
Abdus SaleemGovt. Shalimar Graduate College, Baghbanpura, Lahore 54920, Pakistan.ORCID https://orcid.org/0009-0004-4927-1554
Simone GiovannuzziNeurofarba Department, Sezione di Scienze Farmaceutiche e Nutraceutiche, University of Florence, 50019 Florence, Italy.ORCID https://orcid.org/0000-0002-0669-7481
Claudiu T SupuranNeurofarba Department, Sezione di Scienze Farmaceutiche e Nutraceutiche, University of Florence, 50019 Florence, Italy.ORCID https://orcid.org/0000-0003-4262-0323

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The advent of antibiotic resistance in microorganisms requires the discovery and synthesis of novel antibiotics. At the same time, human pathogens are contributing to chronic and persistent inflammation. Motivated by these two concerning issues, new antibiotic drug candidates are synthesized by incorporation of benzothiazine, pyrazole, and amide moieties in a new scaffold to create multifunctional derivatives of pyrazolo-1,2-benzothiazine. The presented compounds have been synthesized and analyzed using spectroscopic and spectrometric techniques including FTIR, HRMS,

Indexed as

acetamidesantibioticsantimicrobialbenzothiazinesStaphylococcus aureus

Identifiers

PMID39968288
PMCPMC11833175

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.