ArticleJournal of Indian Association of Pediatric Surgeons
Profile of Serum Inflammatory Biomarkers in Children with Peritonitis and their Role in Predicting the Severity and Outcome.
Article in Journal of Indian Association of Pediatric Surgeons. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Review
- Salivary C-Reactive Protein: A Non-Invasive Alternative to Serum CRP in Pediatric Acute Appendicitis.Molecules (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aims and Objectives: The aim of this study was to determine whether the levels of serum inflammatory markers (C-reactive protein [CRP], interleukin-6 [IL-6], calprotectin, and N terminal pro-B-type natriuretic peptide [NT-proBNP]) predict the severity and outcome in children with peritonitis. The primary objective was to evaluate the profile of these serum inflammatory biomarkers in children with peritonitis. The secondary objectives were to correlate the level of these biomarkers with pediatric sequential organ failure assessment (pSOFA) severity score at admission and predict the outcome (mortality). Methods: In this prospective observational study, the level of above serum inflammatory biomarkers in children with peritonitis was measured at the time of admission. The disease severity was assessed using pSOFA score and the association of these biomarkers with the outcomes was studied. Results: A total of 80 children with peritonitis (M: F:: 9:7, mean age: 6.22 ± 3.7 years) were included. The median values of serum CRP, IL-6, calprotectin, and NT-proBNP were 196.88 mg/L (interquartile range [IQR]: 124.37, 285.6), 6.74 pg/ml (IQR: 1.87, 12.54), 46750 μg/L (IQR: 17937.5, 84075), and 365.2 ng/L (IQR: 170, 1034), respectively. Serum CRP and NT-proBNP correlated with pSOFA score. The pSOFA score >4 and serum NT-proBNP were significant in predicting mortality in children with peritonitis ( Conclusion: In children with peritonitis, serum levels of inflammatory biomarkers, i.e. CRP, calprotectin, and NT-proBNP were found to be raised, whereas IL-6 was not raised. The pSOFA score >4 predicted mortality. The serum levels of NT-proBNP were significantly raised in nonsurvivors in children with peritonitis, therefore, can be used as a predictor of severity and mortality in children with peritonitis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.