Evidence map›Paper›PMID 39968212›Full record

ArticleFood science & nutrition2025

Fermented Royal Jelly Enriched With 10-Hydroxydecanoic Acid and Its Potential for Enhancing Mucosal Immunity.

Hayate Itatani, Ayanori Yamaki, Kaori Konishi, Hideto Okamoto, Nobuaki Okumura, Norihiro Shigematsu, Shogo Misumi, Shinji Takenaka

Abstract read
In one paragraph

Article in Food science & nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Royal jelly fermented byBiochemistry and biophysics reports · 2025
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hayate ItataniInstitute for Bee Products & Health Science, R&D Department Yamada Bee Company, Inc. Okayama Japan.ORCID https://orcid.org/0009-0001-1720-7900
Ayanori YamakiInstitute for Bee Products & Health Science, R&D Department Yamada Bee Company, Inc. Okayama Japan.
Kaori KonishiInstitute for Bee Products & Health Science, R&D Department Yamada Bee Company, Inc. Okayama Japan.
Hideto OkamotoInstitute for Bee Products & Health Science, R&D Department Yamada Bee Company, Inc. Okayama Japan.
Nobuaki OkumuraInstitute for Bee Products & Health Science, R&D Department Yamada Bee Company, Inc. Okayama Japan.
Norihiro ShigematsuR&D Department Yamada Bee Company, Inc. Okayama Japan.
Shogo MisumiDepartment of Environmental and Molecular Health Sciences, Faculty of Medical and Pharmaceutical Sciences Kumamoto University Kumamoto Japan.
Shinji TakenakaEnvironmental Microbiology, Division of Agrobioscience, Graduate School of Agricultural Science Kobe University Kobe Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Royal jelly (RJ) is known to contain 10-hydroxydecanoic acid (10HDAA), which has been shown to have immune activation properties, including the promotion of M cell differentiation. However, the natural concentration of 10HDAA in RJ is relatively low. To enhance the functional use of RJ as an immunostimulatory food ingredient, this study aimed to increase its 10HDAA content using bacteria capable of converting 10-hydroxy-2-decenoic acid (10H2DA) to 10HDAA in RJ. A lactic acid bacterium,

Indexed as

10‐hydroxydecanoic acidintestinal immunityLactobacillus panisapiumM cell differentiationroyal jelly

Identifiers

PMID39968212
PMCPMC11833300

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.