ArticleFrontiers in aging neuroscience2025
Investigating dynamic brain functional redundancy as a mechanism of cognitive reserve.
Article in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Associations between life-course cognitive reserve and cognitive domains over 8 years in a large cohort of middle-aged and older adults: The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
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9 authors.
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Abstract
Introduction: Individuals with higher cognitive reserve (CR) are thought to be more resilient to the effects of age-related brain changes on cognitive performance. A potential mechanism of CR is redundancy in brain network functional connectivity (BFR), which refers to the amount of time the brain spends in a redundant state, indicating the presence of multiple independent pathways between brain regions. These can serve as back-up information processing routes, providing resiliency in the presence of stress or disease. In this study we aimed to investigate whether BFR modulates the association between age-related brain changes and cognitive performance across a broad range of cognitive domains. Methods: An open-access neuroimaging and behavioral dataset ( Results: PCA revealed three cognitive test components related to episodic, semantic and executive functioning. Increased BFR predicted reduced performance in episodic functioning when considering cortical thickness and GM volume as measures of BC. BFR significantly modulated the relationship between cortical thickness and episodic functioning. We found neither a predictive nor modulating effect of BFR on semantic or executive performance, nor a significant effect when defining BC via brain age. Discussion: Our results suggest that BFR could serve as a metric of CR when considering certain cognitive domains, specifically episodic functioning, and defined dimensions of BC. These findings potentially indicate the presence of multiple underlying mechanisms of CR.
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