ArticleInternational journal of nanomedicine2025
Folate-Functionalized CS/rGO/NiO Nanocomposites as a Multifunctional Drug Carrier with Anti-Microbial, Target-Specific, and Stimuli-Responsive Capacities.
Article in International journal of nanomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- HIFU-triggered burst release of gallic acid from gelatin/polyvinyl pyrrolidone hydrogel network crosslinked with magnesium gallate MOF.Ultrasonics sonochemistry · 2026Article
- Targeted nanocomposite delivery system of amygdalin using chitosan/reduced graphene oxide-zinc oxide/hyaluronic acid for treatment of head and neck squamous cell carcinoma.BMC oral health · 2026Article
- Zebrafish as a Model for Cardiovascular Disease Using Nanotechnology and Emerging Optogenetic Tools.Biomedicines · 2026Review
- Biodegradable graphene nanocomposites as functional biomaterials: a review of their role in controlled drug delivery and tissue engineering.RSC advances · 2025Review
- Advances in the Application of Graphene and Its Derivatives in Drug Delivery Systems.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Amine-Functionalized NiCoFeInternational journal of nanomedicine · 2025Article
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Authors and funding
6 authors.
Funding
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Abstract
Purpose: This study reports the synthesis of surface-modified chitosan (CS) coated with reduced graphene oxide/nickel oxide (rGO/NiO) as a multifunctional drug carrier with anti-microbial, target-specific, and stimuli-responsive capacities. CS, rGO, and NiO nanoparticles are selected due to their pH-responsiveness, large surface area, and ROS generating-capacity, respectively. Methods: The CS/rGO/NiO nanocomposites (NCs) are synthesized using a solvothermal approach. Glutaraldehyde is used to crosslink CS and rGO/NiO to enhance the stability of the NCs. Structural properties, magnetic properties, antimicrobial activity, drug release sustainability and toxicity of the NCs are evaluated. Results: The NCs show good biocompatibility, excellent magnetic properties, good target specificity, and remarkable cell growth inhibitory effects. The release of doxorubicin (DOX) from the drug-loaded NCs at pH 5.0 (~98.6%) is much higher than that at pH 7.4 (~9.6%). Furthermore, the NCs inhibit the growth of A549 and MCF7 cells, causing the viability of A549 and MCF7 to drop to 12.3% and 7.1%, respectively. By using zebrafish embryos as a model, no detectable change is observed in the survival rate of the embryos after NC treatment. Conclusion: The NCs exhibit multifunctional, target-specific, and pH-responsive characteristics. These properties make the NCs a promising candidate for use in drug delivery applications.
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