ArticleArchives of medical science : AMS2024
The causal association of cheese intake with type 2 diabetes mellitus: results from a two-sample Mendelian randomization study.
Article in Archives of medical science : AMS, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- A digital twin framework for predicting and simulating type 2 diabetes onset using retrospective lifestyle data.Frontiers in digital health · 2026Article
- Causal relationships between depression, anxiety, and myopia: a two-sample Mendelian randomization study.Eye (London, England) · 2025Article
- Assessing the Protective Role of Cheese Consumption Against Type 2 Diabetes and Its Complications: A Mendelian Randomization Study.International journal of endocrinology · 2025Article
- Type 2 diabetes prediction without labs: a systems-level neural framework for risk and behavioral network reorganization.Frontiers in digital health · 2025Article
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Authors and funding
3 authors.
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Abstract
Introduction: Worldwide, type 2 diabetes is a major health concern with numerous risk factors. In observational studies, cheese consumption has been linked to type 2 diabetes, but it is still unclear whether this relationship is causal. To evaluate this relationship, we performed a two-sample Mendelian randomization (MR) study. Material and methods: Summary cheese intake statistics were obtained from UK Biobank and publicly available genome-wide association studies (GWAS) for type 2 diabetes from IEU OpenGWAS, FinnGen Biobank, EBI GWAS, and Biobank Japan. The primary method was pooled meta-analysis with the inverse variance weighting method. The sensitivity analyses included MR-Egger regression, weighted median, weighted mode, and leave-one-out. MR estimations of causation were reported as odds ratios (OR) with 95% confidence intervals (CI). Results: In the pooled meta-analysis of the fixed and random effect model, the combined ORs for type 2 diabetes were 0.58 (95% CI: 0.50-0.68, Conclusions: We found that moderate consumption of beneficial cheese may reduce the risk of type 2 diabetes. These findings suggested that increasing cheese intake appropriate for humans may help prevent and control type 2 diabetes.
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