ArticleSovremennye tekhnologii v meditsine2023
The Model of an Ischemic Non-Healing Wound: Regeneration after Transplantation of a Living Skin.
Article in Sovremennye tekhnologii v meditsine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Non-Healing Wound Model in Diabetic C57BL/6 Mice.Methods and protocols · 2026Article
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Authors and funding
4 authors.
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Abstract
Materials and Methods: The study was performed on 56 BALB/c mice divided into the following groups: "control" (n=19), "scaffold" (n=19), and "LSE" (n=18).During the experiment, the histological, immunohistochemical methods and raster scanning optoacoustic mesoscopy (RSOM) technique were employed to compare the dynamics of regeneration of ischemic non-healing wound using LSE transplantation, collagen-hyaluronic film as a cell scaffold, and a non-treated wound. Results: Histology and immunohistochemistry have been found to be suitable to assess the effectiveness of treating ischemic non-healing wounds during preclinical investigations. The effect of LSE transplantation on infiltration of the wound bed with inflammatory cells, the formation of tissue in the wound bed zone, tissue condition at the wound margins, and angiogenesis has been studied. In addition, a new smoothing coefficient, i.e. the ratio of the thickness of the tissue-remodeling zone to the thickness of the dermis of the wound margins, has been proposed in the study. This coefficient makes it possible to assess the degree of filling the wound bed with the developing tissue. Its high value in the LSE group means that BCP transplantation influences the granulation tissue growth, prevents mechanical stress in the wound preventing thereby cosmetic defects.Exploration of the regenerative processes has shown that the proposed model of the ischemic non-healing wound is suitable for preclinical studies of BCP.
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