Evidence map›Paper›PMID 39967916›Full record

Trial reportSovremennye tekhnologii v meditsine2023

Combined Administration of Nitric Oxide and Hydrogen into Extracorporeal Circuit of Cardiopulmonary Bypass as a Method of Organ Protection during Cardiac Surgery.

V V Pichugin, A V Derugina, S E Domnin, A S Shirshin, S A Fedorov, S N Buranov, S A Jourko, M V Ryazanov, D A Danilova, Yu D Brichkin

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Sovremennye tekhnologii v meditsine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. HMolecular and cellular biochemistry · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

V V PichuginMD, DSc, Professor, Anesthesiologist-Resuscitator; Specialized Cardiosurgical Clinical Hospital named after Academician B.A. Korolev, 209 Vaneeva St., Nizhny Novgorod, 603136, Russia; Professor, Department of Anesthesiology, Intensive Care Medicine, and Transfusiology; Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod, 603005, Russia.
A V DeruginaDSc, Associate Professor, Head of the Department of Physiology and Anatomy; National Research Lobachevsky State University of Nizhny Novgorod, 23 Prospect Gagarina, Nizhny Novgorod, 603022, Russia.
S E DomninMD, PhD, Anesthesiologist-Resuscitator; Specialized Cardiosurgical Clinical Hospital named after Academician B.A. Korolev, 209 Vaneeva St., Nizhny Novgorod, 603136, Russia.
A S ShirshinPhD, Leading Researcher; Russian Federal Nuclear Center - All-Russian Scientific Research Institute of Experimental Physics (RFNC-VNIIEF), 37 Prospect Mira, Sarov, 607188, Russia.
S A FedorovMD, PhD, Cardiovascular Surgeon; Specialized Cardiosurgical Clinical Hospital named after Academician B.A. Korolev, 209 Vaneeva St., Nizhny Novgorod, 603136, Russia.
S N BuranovPhD, Leading Researcher; Russian Federal Nuclear Center - All-Russian Scientific Research Institute of Experimental Physics (RFNC-VNIIEF), 37 Prospect Mira, Sarov, 607188, Russia.
S A JourkoMD, PhD, Head of the Unit, Cardiovascular Surgeon; Specialized Cardiosurgical Clinical Hospital named after Academician B.A. Korolev, 209 Vaneeva St., Nizhny Novgorod, 603136, Russia.
M V RyazanovMD, PhD, Head of the Unit, Cardiovascular Surgeon; Specialized Cardiosurgical Clinical Hospital named after Academician B.A. Korolev, 209 Vaneeva St., Nizhny Novgorod, 603136, Russia; Associate Professor, Department of Hospital Surgery named after B.A. Korolev; Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod, 603005, Russia.
D A DanilovaSenior Tutor, Department of Physiology and Anatomy; National Research Lobachevsky State University of Nizhny Novgorod, 23 Prospect Gagarina, Nizhny Novgorod, 603022, Russia.
Yu D BrichkinMD, DSc, Consulting Professor; Specialized Cardiosurgical Clinical Hospital named after Academician B.A. Korolev, 209 Vaneeva St., Nizhny Novgorod, 603136, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Materials and Methods: The study included 91 patients who underwent heart surgery under CPB. The patients were randomized into 3 groups: group 1 comprised 30 patients (control); group 2 consisted of 33 patients with an isolated supply of nitric oxide (40 ppm) to the extracorporeal circuit; group 3 included 28 patients with a combined supply of nitric oxide (40 ppm) and hydrogen (1.2 ppm) into the extracorporeal circuit. The intensity of lipid peroxidation processes was studied by the content of diene conjugates (DC), triene conjugates (TC), Schiff bases (SB) in blood plasma; erythrocyte aggregation was also examined. The studies were carried out at the following stages: stage 1 (initial) - after induction of anesthesia; stage 2 - before CPB; stage 3 - 5 min after CPB initiation; stage 4 - at the 30 Results: The content of DC increased statistically significantly at the 90 Conclusion: The combined use of gaseous nitric oxide and hydrogen during CPB allowed a statistically significant decrease in the level of activation of lipid peroxidation and erythrocyte aggregation, which ensured a higher level of organ protection during cardiac surgery, faster activation of patients, and a shorter stay in the intensive care unit.

Indexed as

Cardiopulmonary BypassHydrogenNitric OxideAdultAgedAntioxidantsCardiac Surgical ProceduresFemaleHumansLipid PeroxidationMaleMiddle AgedAntioxidantsHydrogenNitric Oxidecardiopulmonary bypassheart surgeryhydrogennitric oxide

Identifiers

PMID39967916
PMCPMC11832070

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.