Evidence map›Paper›PMID 39967874›Full record

ArticleiScience2025

Rapid and relaying deleterious effects of a gastrointestinal pathogen,

Kunal Sharan, Cordelia Brandt, Mohd Aslam Yusuf, Parminder Singh, Namrita Halder, Madeline E Edwards, Svvs Ravi Mangu, Abhilipsa Das, Amrita Mishra, Shashi S Kumar and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Rehydration rescues Il22Nature communications · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Kunal SharanMouse Genetics Project, Wellcome Sanger Institute, Hinxton, Saffron Walden, UK.
Cordelia BrandtHost-Pathogen Interaction Group, Wellcome Sanger Institute, Hinxton, Saffron Walden, UK.
Mohd Aslam YusufDepartment of Bioengineering, Integral University, Lucknow, Uttar Pradesh, India.
Parminder SinghNational Institute of Immunology, New Delhi, New Delhi, India.
Namrita HalderNational Centre for Cell Science, Pune, Maharastra, India.
Madeline E EdwardsDepartment of Microbiology and Immunology, Columbia University, New York, NY, USA.
Svvs Ravi ManguDepartment of Molecular Nutrition, CSIR-CFTRI, Mysore, Karnataka, India.
Abhilipsa DasDepartment of Molecular Nutrition, CSIR-CFTRI, Mysore, Karnataka, India.
Amrita MishraNational Centre for Cell Science, Pune, Maharastra, India.
Shashi S KumarCenter for Motor Neuron Biology & Disease, Columbia University, New York, NY, USA.
Amita SharmaPediatric Kidney Foundation, New Delhi, New Delhi, India.
Alka GuptaReproductive Biology Laboratory, National Institute of Immunology, New Delhi, New Delhi, India.
Xiaowei S LiuDepartment of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA, USA.
Edward X GuoBone Biomechanics Laboratory, Columbia University, New York, NY, USA.
Umrao R MonaniCenter for Motor Neuron Biology & Disease, Columbia University, New York, NY, USA.
Devasena PonnalaguDepartment of Pharmacology, University of Washington, Seattle, WA, USA.
Ivaylo I IvanovDepartment of Microbiology and Immunology, Columbia University, New York, NY, USA.
Girdhari LalNational Centre for Cell Science, Pune, Maharastra, India.
Simon ClareHost-Pathogen Interaction Group, Wellcome Sanger Institute, Hinxton, Saffron Walden, UK.
Gordon DouganHost-Pathogen Interaction Group, Wellcome Sanger Institute, Hinxton, Saffron Walden, UK.
Vijay K YadavMouse Genetics Project, Wellcome Sanger Institute, Hinxton, Saffron Walden, UK.

Funding

Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anil K Rustgi · 1985 to 2026
$115.3M
Role of intestinal commensal-induced Th17 cells and mucosal immunity in metabolic diseaseR01DK098378 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Ivaylo Ivanov Ivanov · 2013 to 2026
$6.5M
Maintenance of mucosal homeostasis by commensal Th17 cellsU01AI163069 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Ivaylo Ivanov Ivanov · 2021 to 2026
$2.8M
Non-redundant functions of type 3 innate lymphoid cells in mucosal immunityR01AI144808 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI IVANOV, IVAYLO IVANOV · 2019 to 2022
$1.9M
Regulation of adrenal development and function by the mother's skeletonR01HD107574 · NICHD · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI YADAV, VIJAY K · 2021 to 2025
$1.7M
Taurine, an endogenously produced semi-essential micronutrient, as a regulator of lifespan and healthspanR56AG079980 · NIA · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI YADAV, VIJAY K · 2023 to 2023
$657k
NCI NIH HHS P30 CA013696NIAID NIH HHS R01 AI144808NIAID NIH HHS U01 AI163069NIA NIH HHS R56 AG079980NICHD NIH HHS R01 HD107574NIDDK NIH HHS R01 DK098378
6 · The paper itself

Abstract

Enteropathogenic infections cause pathophysiological changes in the host but their effects beyond the gastrointestinal tract are undefined. Here, using

Indexed as

GastroenterologyImmune responseMolecular physiology

Identifiers

PMID39967874
PMCPMC11834125

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.