ArticleNeuropsychiatric disease and treatment2025
Modulating Gut Microbiota: The Mechanism of Electroacupuncture at the "Siguan" Acupoints in Alleviating Post-Stroke Depression.
Article in Neuropsychiatric disease and treatment, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Traditional Chinese Medicine Ameliorates Depression via the Gut-Brain Axis: A Review Focus on NLRP3/TLR4-Mediated Inflammatory Pathways and Gut Microbiota Modulation.Neuropsychiatric disease and treatment · 2026Review
- Novel insights of acupuncture in ischemic stroke: orchestrating neuro-endocrine-immune network.Frontiers in immunology · 2026Review
- Acupuncture Modulation of the Microbiota-Gut-Brain Axis in Major Depressive Disorder: Integrative Mechanisms, Emerging Evidence, and Future Therapeutic Perspectives.Neuropsychiatric disease and treatment · 2026Review
- Does the Microbiota-Gut-Brain Axis Mediate the Antidepressant Effects of Acupuncture? A Structured Review of Preclinical and Clinical Evidence.Neuropsychiatric disease and treatment · 2026Review
- Intestinal Flora Reconfiguration via Electroacupuncture: A Strategy to Counteract Depressive-Like Symptoms in Rats.Neuropsychiatric disease and treatment · 2026Article
- Synergistic Effect of Acupuncture and Traditional Chinese Medicine on Cerebral Infarction in Rats: Roles of Short-Chain Fatty Acids and Interleukin-17.International journal of general medicine · 2025Article
- Insights of acupuncture in modulating gut microbiota in stroke treatment.Frontiers in neurology · 2025Review
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7 authors.
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Abstract
Purpose: To explore the related mechanisms of electroacupuncture at the "Siguan" acupoints in treating post-stroke depression (PSD). Methods: Fifty male SD rats were randomly divided into the blank group, stroke group, PSD group, Siguan group and Bifidobacterium group, with 10 rats in each group. The Siguan group was given electroacupuncture at the bilateral "Hegu" (LI4) and "Taichong" (LR3), using the disperse-dense wave with a frequency of 2Hz/10Hz for 30 minutes each time. The changes in depressive behaviors of rats were observed according to the sucrose consumption and the scores of the open field test of rats in each group. The gene data of the intestinal flora of rats in each group were extracted to analyze the differences in the diversity, composition structure and function of the intestinal flora among different groups. Results: The scores of the depression behavior indexes of the PSD rats in the Siguan group were higher than those in the PSD group. Meanwhile, there were disorders in the structure and function of the intestinal flora of the PSD rats. Compared with the PSD group, both the Siguan group and the Bifidobacterium group had increased contents of beneficial bacteria (Firmicutes and Clostridia) and decreased contents of pathogenic bacteria (Bacteroidetes and Bacteroidia). Compared with the PSD group, the intestinal flora structures of the Siguan group and the Bifidobacterium group were closer to those of normal rats. The abundance of the "Metabolism of Cofactors and Vitamins" functional pathway of the intestinal flora in the Siguan group was lower than that in the PSD group. Conclusion: Electroacupuncture at the "Siguan" acupoints can improve the depression-like behaviors of PSD rats by up-regulating intestinal probiotics, down-regulating pathogenic bacteria, restoring the physiological structure of the intestinal flora and regulating the function of the intestinal flora.
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