ArticleRegenerative therapy2025
Effects of basic fibroblast growth factor on cartilage to bone: Time-course histological analysis of
Article in Regenerative therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Effects and mechanisms of synovial mesenchymal stem cell-derived extracellular vesicular LncRNA-SNHG14 on chondrocyte injury.Regenerative therapy · 2026Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Cartilage tissue is important in the human body as a ubiquitous connective tissue. However, information on the limits of chondrocyte growth and the effects of basic FGF (bFGF) Methods: Chondrocytes were isolated from the epiphyseal cartilage derived from the digits of polydactyly patients and were cultivated in a medium supplemented with bFGF (bFGF-treated cells) and without bFGF (bFGF-untreated cells). These cultivated cells were subcutaneously implanted into the backs of NOG mice. Results: bFGF-treated cells exhibited a higher growth rate than bFGF-untreated cells. Cartilage was formed after two weeks of implantation. The cartilages generated by bFGF-treated cells (denoted as "BT-cartilage" hereafter) were larger in size and heavier in weight than those cartilages generated by bFGF-untreated cells (denoted as "BUT-cartilage" hereafter). BT-cartilage grew exponentially after 10 weeks. Conclusions: From these results, bFGF-treated cells exhibited increased ability for both proliferation and differentiation compared to bFGF-untreated cells. The results of this study may lead to the generation of new alternative therapies for bone and cartilage through the use of epiphyseal chondrocytes.
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Registered trials
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