Evidence map›Paper›PMID 39967751›Full record

ArticleSouthern African journal of HIV medicine2025

Kidney disease among adults on tenofovir-based second-line antiretroviral therapy in Dar es Salaam, Tanzania.

Sabina F Mugusi, Grace A Shayo, Philip G Sasi, Lulu S Fundikira, Eric A Aris, Christopher R Sudfeld, Ferdinand M Mugusi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Southern African journal of HIV medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sabina F MugusiDepartment of Clinical Pharmacology, School of Biomedical Sciences, Muhimbili University of Health and Allied Sciences, Dar es Salaam, United Republic of Tanzania.ORCID https://orcid.org/0000-0003-3367-0564
Grace A ShayoDepartment of Internal Medicine, School of Clinical Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, United Republic of Tanzania.ORCID https://orcid.org/0000-0001-9482-8703
Philip G SasiDepartment of Clinical Pharmacology, School of Biomedical Sciences, Muhimbili University of Health and Allied Sciences, Dar es Salaam, United Republic of Tanzania.ORCID https://orcid.org/0000-0002-9911-8302
Lulu S FundikiraDepartment of Radiology and Imaging, School of Diagnostic Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, United Republic of Tanzania.ORCID https://orcid.org/0000-0002-4953-7699
Eric A ArisManagement and Development for Health, Dar es Salaam, United Republic of Tanzania.ORCID https://orcid.org/0009-0006-7647-5135
Christopher R SudfeldDepartment of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, United States of America.ORCID https://orcid.org/0000-0002-3203-3638
Ferdinand M MugusiDepartment of Internal Medicine, School of Clinical Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, United Republic of Tanzania.ORCID https://orcid.org/0000-0001-7479-4913

Funding

Training Tanzanian Researchers for HIV/AIDS Implementation ScienceD43TW009775 · FIC · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Wafaie W Fawzi, Christopher Sudfeld · 2015 to 2026
$3.0M
FIC NIH HHS D43 TW009775
6 · The paper itself

Abstract

Background: Kidney disease is a growing non-AIDS-related comorbidity among people living with HIV (PLWH). Tenofovir disoproxil fumarate (TDF) can result in proximal tubulopathy and acute tubular injury, whereas atazanavir/ritonavir (ATV/r) can cause interstitial nephritis and renal stones, both of which can lead to chronic kidney disease. Objectives: To examine the relationship between second-line combination antiretroviral therapy (ART) and the risk of kidney disease and morphological changes among PLWH in Dar es Salaam, Tanzania. Method: A cross-sectional study of adult PLWH receiving TDF-based second-line ART. Socio-demographic and clinical data were gathered, and laboratory tests were conducted to determine the estimated glomerular filtration rate (eGFR). Ultrasonography was performed to visualise the kidneys. Results: A total of 323 patients were enrolled (67.8% women), with a median age of 44 (interquartile range [IQR]: 39-51) years. Patients were on second-line ART for a median of 49 [IQR: 25-73] months, and 60% received ATV/r. Low eGFR (< 90 mL/min per 1.73 m Conclusion: Adults on second-line ART containing TDF were found to have a high prevalence of renal kidney disease in the Tanzanian context. Predictors of kidney disease were older age, proteinuria, and ATV/r-based regimen as compared to LPV/r.

Indexed as

atazanavir sulfatecombination antiretroviral therapyHIVkidney diseasetenofovir

Identifiers

PMID39967751
PMCPMC11830870

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.