Evidence map›Paper›PMID 39967675›Full record

ArticleFrontiers in immunology2025

Challenging the notion of endothelial infection by SARS-CoV-2: insights from the current scientific evidence.

Saravanan Subramaniam, Asha Jose, Devin Kenney, Aoife K O'Connell, Markus Bosmann, Florian Douam, Nicholas Crossland

Abstract read
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Saravanan SubramaniamDepartment of Pharmacology and Toxicology, Massachusetts College of Pharmacy and Health Sciences, Boston, MA, United States.
Asha JoseRenal Section, Department of Medicine, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA, United States.
Devin KenneyDepartment of Virology, Immunology and Microbiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, United States.
Aoife K O'ConnellNational Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston, MA, United States.
Markus BosmannDepartment of Medicine, Pulmonary Center, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA, United States.
Florian DouamDepartment of Virology, Immunology and Microbiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, United States.
Nicholas CrosslandDepartment of Virology, Immunology and Microbiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, United States.

Funding

Project-005UL1TR001430 · NCATS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BAIR-MERRITT, MEGAN H, CENTER, DAVID M. · 2015 to 2024
$52.3M
Role reversal of MAVS in bacterial sepsisR01HL141513 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BOSMANN, MARKUS · 2018 to 2022
$2.4M
New genetic models for C5a receptorsR01HL139641 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BOSMANN, MARKUS · 2018 to 2022
$2.1M
Vectra Polaris Quantitative Pathology Imaging SystemS10OD030269 · OD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CROSSLAND, NICHOLAS ALEXANDER · 2021 to 2021
$402k
Ventana Discovery Ultra Research Autostainer: an Ex+ Core serviceS10OD026983 · OD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CROSSLAND, NICHOLAS ALEXANDER · 2019 to 2019
$207k
NCATS NIH HHS UL1 TR001430NHLBI NIH HHS R01 HL139641NHLBI NIH HHS R01 HL141513NIH HHS S10 OD026983NIH HHS S10 OD030269
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

coreceptorsCOVID-19endothelial cells (EC)endothelial infectionSARS-CoV-2

Identifiers

PMID39967675
PMCPMC11832389

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.