Evidence map›Paper›PMID 39967623›Full record

ArticleACS medicinal chemistry letters2025

Use of Aldehyde-Alkyne-Amine Couplings to Generate Medicinal Chemistry-Relevant Linkers.

Andrew McGown, Vesna Vetma, Damien Crepin, Yan Lin, Claire Adcock, Conner Craigon, Jordan Nafie, Daniel von Emloh, Léa Sutton, Kiera Bailey and 9 more

Abstract read
In one paragraph

Article in ACS medicinal chemistry letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Andrew McGownSussex Drug Discovery Centre, School of Life Sciences, University of Sussex, Falmer BN1 9QJ, U.K.
Vesna VetmaCentre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, 1 James Lindsay Place, Dundee DD1 5JJ, U.K.ORCID https://orcid.org/0000-0003-4013-6917
Damien CrepinSussex Drug Discovery Centre, School of Life Sciences, University of Sussex, Falmer BN1 9QJ, U.K.
Yan LinSussex Drug Discovery Centre, School of Life Sciences, University of Sussex, Falmer BN1 9QJ, U.K.
Claire AdcockSussex Drug Discovery Centre, School of Life Sciences, University of Sussex, Falmer BN1 9QJ, U.K.
Conner CraigonCentre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, 1 James Lindsay Place, Dundee DD1 5JJ, U.K.ORCID https://orcid.org/0000-0001-8649-6876
Jordan NafieBiotools, Inc., 17546 Beeline Highway, Jupiter, Florida 33458, United States.
Daniel von EmlohReach Separations, Biocity, Pennyfoot Lane, Nottingham NG1 1GF, U.K.
Léa SuttonReach Separations, Biocity, Pennyfoot Lane, Nottingham NG1 1GF, U.K.ORCID https://orcid.org/0009-0003-6883-9611
Kiera BaileyReach Separations, Biocity, Pennyfoot Lane, Nottingham NG1 1GF, U.K.
Lewis EdmundsReach Separations, Biocity, Pennyfoot Lane, Nottingham NG1 1GF, U.K.
Manvendra SharmaChemistry Department, School of Life Sciences, University of Sussex, Falmer BN1 9QJ, U.K.
Jonathan D WildenChemistry Department, School of Life Sciences, University of Sussex, Falmer BN1 9QJ, U.K.ORCID https://orcid.org/0000-0003-4269-2714
Simon J ColesNational Crystallography Service Chemistry, University of Southampton, Southampton SO171BJ, U.K.ORCID https://orcid.org/0000-0001-8414-9272
Graham J TizzardNational Crystallography Service Chemistry, University of Southampton, Southampton SO171BJ, U.K.
William FarnabyCentre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, 1 James Lindsay Place, Dundee DD1 5JJ, U.K.
Alessio CiulliCentre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, 1 James Lindsay Place, Dundee DD1 5JJ, U.K.ORCID https://orcid.org/0000-0002-8654-1670
George E KostakisChemistry Department, School of Life Sciences, University of Sussex, Falmer BN1 9QJ, U.K.ORCID https://orcid.org/0000-0002-4316-4369
John SpencerSussex Drug Discovery Centre, School of Life Sciences, University of Sussex, Falmer BN1 9QJ, U.K.ORCID https://orcid.org/0000-0001-5231-8836

Funding

Wellcome Trust
6 · The paper itself

Abstract

Copper catalyzed aldehyde-alkyne-amine (A

Identifiers

PMID39967623
PMCPMC11831382

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.