Evidence map›Paper›PMID 39967381›Full record

Trial reportJournal of the International Society of Sports Nutrition2025

Acute effects of isolated and combined dietary nitrate and caffeine ingestion on ergometer-based 1000 m time trial performance in highly trained kayakers.

Johannes Pollex, Martin Behrens, Thomas Mittlmeier, Sven Bruhn, Matthias Weippert

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of the International Society of Sports Nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Johannes PollexUniversity of Rostock, Institute of Sport Science, Rostock, Germany.
Martin BehrensUniversity of Applied Sciences for Sport and Management Potsdam, Research and Analysis Methods in Sports Science, Potsdam, Germany.ORCID 0000-0003-1980-3260
Thomas MittlmeierRostock University Medical Center, Department of Trauma, Hand and Reconstructive Surgery, Rostock, Germany.ORCID 0000-0002-0536-8045
Sven BruhnUniversity of Rostock, Institute of Sport Science, Rostock, Germany.
Matthias WeippertUniversity of Rostock, Institute of Sport Science, Rostock, Germany.ORCID 0000-0003-2323-0047

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDietary nitrate (BR) and caffeine (CAF) ingestion have been shown to increase sports performance. However, the isolated and combined effects of BR and CAF ingestion on time trial (TT) performance as well as the accompanying physiological and perceptual responses have never been investigated in highly trained kayak athletes. Therefore, the present study examined the impact of an isolated and combined supplementation with BR (140 ml beetroot concentrate, ~12.5 mmol nitrate) and CAF (3 mg/kg bodyweight) on 1000 m ergometer TT performance as well as the accompanying physiological (i.e. cardiorespiratory function, muscle oxygenation, muscle activity) and perceptual responses (i.e. fatigue, effort, and exercise-induced pain perception) in male highly trained kayakers. It was hypothesized that the isolated ingestion of BR and CAF would both improve ergometer-based 1000 m TT performance and induce supplement-specific physiological and perceptual responses. Considering the primary effects of BR on muscle function and of CAF on the central nervous system, it was further assumed that the combined ingestion will result in an additional performance increase and supplement-specific physiological and perceptual responses.

methodsUsing a prospective, randomized, controlled, double-blind crossover design, 12 male highly trained kayak athletes from local clubs were investigated. They completed four measurement sessions resulting in four randomized conditions: (i) BR+CAF; (ii) BR+CAF placebo (BR+PLA); (iii) CAF+BR placebo (CAF+PLA); and (iv) BR placebo + CAF placebo (PLA+PLA). An air-braked instrumented kayak-ergometer was used to record 1000 m TT performance, power output, and stroke frequency. Heart rate (HR), oxygen uptake (VO

resultsThe supplements did not have an ergogenic effect on TT performance compared to the PLA+PLA condition, either in isolation or in combination. The same applied to the majority of physiological parameters and the perceptual responses. Nevertheless, VE/VO

conclusionsData indicate that the isolated and combined ingestion of BR and CAF had no effect on 1000 m TT performance, the majority of physiological responses, and perceptual responses in highly trained kayakers. These findings might be related to the dosage and/or a ceiling effect due to the already efficient vascular, metabolic, and muscle function, including high amounts of endogenous produced nitric oxide, in athletes.

Indexed as

Athletic PerformanceCaffeineNitratesPerformance-Enhancing SubstancesWater SportsAdultCross-Over StudiesDietary SupplementsDouble-Blind MethodErgometryHeart RateHumansMaleMuscle, SkeletalOxygen ConsumptionProspective StudiesCaffeineNitratesPerformance-Enhancing Substancesergogenic supplementshighly trained kayak athletesKayak time trial performancemuscle activitymuscle oxygenationoxygen uptake

Identifiers

PMID39967381
PMCPMC11841103

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.