Evidence map›Paper›PMID 39967321›Full record

ArticleJournal of the peripheral nervous system : JPNS2025

Unique Nerve Tissue-Restricted T-Cell Clones in Chronic Inflammatory Demyelinating Polyneuropathy.

G G A van Lieverloo, D C Anang, M E Adrichem, B A Coert, A E Aronica, L Wieske, I N van Schaik, N de Vries, F Eftimov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the peripheral nervous system : JPNS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

G G A van LieverlooAmsterdam Rheumatology and Immunology Center Amsterdam, Department of Clinical Immunology and Rheumatology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.ORCID 0000-0002-2690-728X
D C AnangAmsterdam Rheumatology and Immunology Center Amsterdam, Department of Clinical Immunology and Rheumatology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
M E AdrichemDepartment of Neurology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
B A CoertDepartment of Neurosurgery, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
A E AronicaDepartment of Neuropathology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
L WieskeDepartment of Neurology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.ORCID 0000-0002-2522-4081
I N van SchaikDepartment of Neurology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
N de VriesAmsterdam Rheumatology and Immunology Center Amsterdam, Department of Clinical Immunology and Rheumatology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
F EftimovDepartment of Neurology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.

Funding

Peripheral Nerve Society/Baxter FellowshipPrinses Beatrix Spierfonds W.OR12-09
6 · The paper itself

Abstract

BACKGROUND AND

aimsChronic inflammatory demyelinating polyneuropathy (CIDP) is an immune-mediated disorder characterized by peripheral nerve damage. Although T lymphocytes (T-cells) are implicated in the pathogenesis of CIDP, we previously observed that the frequency of highly expanded T-cell clones (HECs) in peripheral blood of CIDP patients was not different from healthy controls. To investigate if local T-cells might be pathogenic, we employed next-generation sequencing to compare the TCRβ repertoire between peripheral blood and nerve tissue of CIDP patients.

methodsAdaptive immune receptor repertoire sequencing (AIRR-Seq) of the TCRβ chain was conducted on peripheral blood and nerve tissue obtained from three newly diagnosed CIDP patients.

resultsAll patients showed high numbers of highly expanded TCRβ clones in nerve tissue that were not detected or detected only in very low frequencies in blood, whereas in blood other HECs were found. Clustering analysis based on CDR3-similarity showed that these nerve tissue-restricted TCRβ clones were distinct from blood clones, as evidenced by the absence of prominent clusters.

interpretationUnique nerve tissue-restricted TCRβ clones may indicate a highly localized immune response with localized expansion and/or retention of T-cells that could contribute to the pathomechanism of CIDP. Further characterization of the phenotype, antigen target and functionality of these T-cells is essential to determine their pathogenic role.

Indexed as

Nerve TissuePolyradiculoneuropathy, Chronic Inflammatory DemyelinatingReceptors, Antigen, T-Cell, alpha-betaT-LymphocytesAdultAgedClone CellsFemaleHumansMaleMiddle AgedReceptors, Antigen, T-Cell, alpha-betaCIDPclonalitynervenext‐generation sequencingT‐cell receptor repertoire

Identifiers

PMID39967321
PMCPMC11836545

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.