Evidence map›Paper›PMID 39967231›Full record

ArticleAlimentary pharmacology & therapeutics2025

Comparison Between Dynamic Models for Predicting Response to Corticosteroids in Alcohol-Associated Hepatitis: A Global Cohort Study.

Francisco Idalsoaga, Luis Antonio Díaz, Leonardo Guizzetti, Winston Dunn, Heer Mehta, Jorge Arnold, Gustavo Ayares, Rokhsana Mortuza, Gurpreet Mahli, Alvi H Islam and 28 more

Abstract readComparative StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Alimentary pharmacology & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors.

Francisco IdalsoagaDivision of Gastroenterology and Hepatology, Western University & London Health Sciences Centre, London, Canada.ORCID https://orcid.org/0000-0001-5607-0698
Luis Antonio DíazDepartamento de Gastroenterología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.ORCID https://orcid.org/0000-0002-8540-4930
Leonardo GuizzettiMaple Statistical Consulting, Ottawa, Canada.ORCID https://orcid.org/0000-0001-5864-8422
Winston DunnDivision of Gastroenterology, Department of Medicine, University of Kansas Medical Center, Kansas City, Missouri, USA.ORCID https://orcid.org/0000-0002-4246-6998
Heer MehtaDivision of Gastroenterology, Department of Medicine, University of Kansas Medical Center, Kansas City, Missouri, USA.ORCID https://orcid.org/0000-0002-5357-2112
Jorge ArnoldDepartamento de Gastroenterología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.ORCID https://orcid.org/0000-0003-2139-5120
Gustavo AyaresDepartamento de Gastroenterología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.ORCID https://orcid.org/0000-0002-8651-2255
Rokhsana MortuzaDivision of Gastroenterology and Hepatology, Western University & London Health Sciences Centre, London, Canada.ORCID https://orcid.org/0000-0001-9586-9371
Gurpreet MahliDivision of Gastroenterology and Hepatology, Western University & London Health Sciences Centre, London, Canada.
Alvi H IslamDivision of Gastroenterology and Hepatology, Western University & London Health Sciences Centre, London, Canada.
Shiv K SarinDepartment of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India.ORCID https://orcid.org/0000-0002-0544-5610
Rakhi MaiwallDepartment of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India.ORCID https://orcid.org/0000-0003-0110-5982
Wei ZhangGastroenterology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Steve QianDivision of Gastroenterology and Hepatology, University of Florida, Gainesville, Florida, USA.ORCID https://orcid.org/0000-0002-2840-1696
Douglas SimonettoDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.ORCID https://orcid.org/0000-0003-4095-8144
Ashwani K SingalDivision of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky, USA.ORCID https://orcid.org/0000-0003-1207-3998
Mohamed A ElfekiDivision of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky, USA.ORCID https://orcid.org/0000-0002-5623-2770
Carolina Ramirez-CadizDepartment of Anesthesiology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.ORCID https://orcid.org/0000-0002-6805-0560
Joaquín CabezasGastroenterology and Hepatology Department, University Hospital Marqués de Valdecilla, Santander, Spain.ORCID https://orcid.org/0000-0003-0012-484X
Victor EchavarríaGastroenterology and Hepatology Department, University Hospital Marqués de Valdecilla, Santander, Spain.ORCID https://orcid.org/0000-0001-9513-2855
Meritxell Ventura CotsLiver Unit, Hospital Vall D'hebron, Universitat Autonoma Barcelona, Ciberehd, Barcelona, Spain.
María Fátima Higuera-De La TijeraServicio de Gastroenterología, Hospital General De México, Universidad Nacional Autónoma de México, Mexico City, Mexico.ORCID https://orcid.org/0000-0003-1862-7541
Juan G AbraldesDivision of Gastroenterology, Liver Unit, University of Alberta, Edmonton, Alberta, Canada.ORCID https://orcid.org/0000-0003-3421-937X
Mustafa Al-KaraghouliDivision of Gastroenterology, Liver Unit, University of Alberta, Edmonton, Alberta, Canada.
Prasun K JalalDepartment of Gastroenterology and Hepatology, Baylor College of Medicine, Houston, Texas, USA.ORCID https://orcid.org/0000-0001-5353-2324
Mohamad Ali IbrahimDepartment of Gastroenterology and Hepatology, Baylor College of Medicine, Houston, Texas, USA.
Guadalupe García-TsaoSection of Digestive Diseases, Yale University School of Medicine/VA-CTt Healthcare System, New Haven/West Haven, Connecticut, USA.ORCID https://orcid.org/0000-0001-8371-4524
Daniela GoyesSection of Digestive Diseases, Yale University School of Medicine/VA-CTt Healthcare System, New Haven/West Haven, Connecticut, USA.
Lubomir SkladanýDivision of Hepatology, Gastroenterology and Liver Transplantation, Department of Internal Medicine II, Slovak Medical University, F. D. Roosevelt University Hospital, Banska Bystrica, Slovak Republic.ORCID https://orcid.org/0000-0001-5171-3623
Daniel J HavajDivision of Hepatology, Gastroenterology and Liver Transplantation, Department of Internal Medicine II, Slovak Medical University, F. D. Roosevelt University Hospital, Banska Bystrica, Slovak Republic.ORCID https://orcid.org/0000-0001-5979-8326
Karolina SulejovaDivision of Hepatology, Gastroenterology and Liver Transplantation, Department of Internal Medicine II, Slovak Medical University, F. D. Roosevelt University Hospital, Banska Bystrica, Slovak Republic.
Svetlana Adamcova SelcanovaDivision of Hepatology, Gastroenterology and Liver Transplantation, Department of Internal Medicine II, Slovak Medical University, F. D. Roosevelt University Hospital, Banska Bystrica, Slovak Republic.
Diego RincónLiver Unit, Department of Digestive Diseases Hospital General, Universitario Gregorio Marañón, Madrid, Spain.
Vijay H ShahDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Patrick S KamathDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.ORCID https://orcid.org/0000-0002-7888-1165
Marco ArreseDepartamento de Gastroenterología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.ORCID https://orcid.org/0000-0002-0499-4191
Ramon BatallerLiver Unit, Hospital Clinic, Barcelona, Spain.ORCID https://orcid.org/0000-0002-1119-7799
Juan Pablo ArabDepartamento de Gastroenterología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.ORCID https://orcid.org/0000-0002-8561-396X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several dynamic models predict mortality and corticosteroid response in alcohol-associated hepatitis (AH), yet no consensus exists on the most effective model. This study aimed to assess predictive models for corticosteroid response and short-term mortality in severe AH within a global cohort. We conducted a multi-national study of patients with severe AH treated with corticosteroids for at least 7 days, enrolled between 2009 and 2019. Dynamic models-Lille-4, Lille-7, trajectory of serum bilirubin (TSB), and neutrophil-to-lymphocyte ratio (NLR)-were used to estimate 30- and 90-day mortality. Lille-7 demonstrated the highest accuracy for both 30- and 90-day mortality.

Indexed as

Adrenal Cortex HormonesHepatitis, AlcoholicAdultAgedBilirubinCohort StudiesFemaleHumansMaleMiddle AgedNeutrophilsTreatment OutcomeAdrenal Cortex HormonesBilirubinalcoholalcohol‐associated liver diseasealcoholic cirrhosisalcohol‐related hepatitiscirrhosisend‐stage liver diseaseoutcome prediction

Identifiers

PMID39967231
PMCPMC11950807

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.