ArticleClinical and experimental dental research2025
Radicular Cysts and Periapical Granulomas: Data Documentation for 696 Cases and Findings on Fibrosis, and Porphyromonas gingivalis and Fusobacterium nucleatum in These Lesions.
Article in Clinical and experimental dental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Improbable healing in endodontics: a case series of favorable outcomes despite adverse prognostic conditions.BMC oral health · 2026Article
- Functional heterogeneity and health impacts of oral bacterial ectopic colonization.Frontiers in microbiology · 2026Review
- The Presence and Tissue Distribution ofInternational journal of dentistry · 2026Article
- Fusobacterium nucleatum: a transboundary pathogen in host-microbiota networks.Gut pathogens · 2025Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectiveThe objective of our study was to re-evaluate periapical lesions, including radicular cysts (RCs) and periapical granulomas (PGs) for locations, histopathological features, and degree of fibrosis in relation to the inflammatory response. In addition, we examined the presence of Porphyromonas gingivalis (Pg) and Fusobacterium nucleatum (Fn) since both are widely recognized pathogens in periodontal infections.
methodsWe re-evaluated samples of RCs and PGs (n = 728) and collected data for analyses by IBM's SPSS Statistics. Among these samples, we stained 93 samples to determine the immunoexpression of Pg and Fn. For immunostaining, we used Gingipain R1 antibody for Pg and Rabbit anti-Fn antibody for Fn.
resultsFibrosis is associated with mild inflammation. We found a significant positive correlation between Pg and Fn. Thus, these pathogens are likely to occur together in periapical inflammatory lesions. We additionally noted that these periodontopathic pathogens are more likely to be present in RCs than in PGs.
conclusionsAsymptomatic radiologically diagnosed periapical lesions may not necessarily need root canal retreatment in healthy patients since these lesions may represent scar tissue rather than active apical periodontitis. Clinical and radiological follow-up is still needed. Yet, periapical lesions, especially cysts, may contain dystopic periodontopathic pathogens, and Pg and Fn often occur together in periapical lesions.
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