ReviewChembiochem : a European journal of chemical biology2025
d-Alanine, a Circadian Metabolite that Regulates Glucose Metabolism and Viral Infection.
Review in Chembiochem : a European journal of chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Gut microbiota composition and functional pathways associated with metabolic syndrome in Mexican adult women: cross-sectional analysis.BMC microbiology · 2026Article
- Theoretical Analysis of d-Serine and d-Asparagine as Biomarkers for Glomerular Filtration Rate.Chemistry & biodiversity · 2025Review
- d-Alanine, a Circadian Metabolite that Regulates Glucose Metabolism and Viral Infection.Chembiochem : a European journal of chemical biology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
d-Alanine, a rare d-amino acid, exhibits a clear circadian rhythm and is present in organs associated with glucose metabolism. Recent findings have revealed that d-alanine acts on the circadian rhythm, thereby regulating physiological processes related to circadian cycles that are essential for maintaining body homeostasis. The regulation of circadian rhythm by d-alanine is vital for correcting blood glucose levels in diabetic conditions. In viral infections, d-alanine serves as a sensitive biomarker that reflects the severity of the infection, as its level drastically decreases due to consumption. Supplementation with d-alanine is effective to alleviate the progression of viral infections, potentially through the maintenance of the circadian rhythm and its associated immune responses. In addition to its role as a circadian biomarker, d-alanine also functions as a circadian regulator and exerts a wide range of physiological effects. This review summarizes the physiological roles of d-alanine as a circadian metabolite.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.