Evidence map›Paper›PMID 39966992›Full record

ArticleEuropean journal of medical research2025

Effect of salmon calcitonin combined with calcium antagonist on blood calcium and phosphorus ion concentration in osteoporosis rats.

Jiahao Chen, Jie Wang, Wenlu Jia, Yakun Zhang, Haimei Li, Shunmei Liu, Hengyi Sun

Abstract read
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In one paragraph

Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Jiahao Chen *School of Biosciences and Technology, Shandong Second Medical University, Weifang, 261053, Shandong, China.
Jie Wang *School of Biosciences and Technology, Shandong Second Medical University, Weifang, 261053, Shandong, China.
Wenlu JiaSchool of Biosciences and Technology, Shandong Second Medical University, Weifang, 261053, Shandong, China.
Yakun ZhangSchool of Biosciences and Technology, Shandong Second Medical University, Weifang, 261053, Shandong, China.
Haimei LiSchool of Biosciences and Technology, Shandong Second Medical University, Weifang, 261053, Shandong, China.
Shunmei LiuSchool of Biosciences and Technology, Shandong Second Medical University, Weifang, 261053, Shandong, China.
Hengyi SunSchool of Biosciences and Technology, Shandong Second Medical University, Weifang, 261053, Shandong, China. sunhengyi1987@sdsmu.edu.cn.

Funding

Natural Science Foundation of Shandong Province ZR2019BH035the National Science Foundation of China 82104053The project of youth creation team in Shandong higher education institutions 2022KJ26the Science and Technology Development Program in Weifang 2020GX014
6 · The paper itself

Abstract

backgroundOur research aims to explore the effect of salmon calcitonin (sCT) combined with three calcium antagonists (CCA), verapamil, nifedipine and diltiazem, on calcium and phosphorus ion metabolism in the blood of osteoporotic female rats following ovarian removal. To explore a method of combination medication suitable for postmenopausal women with osteoporosis.

methodsWe first carried out the combined drug experiment on rats, and then carried out the combined drug experiment on osteoporosis rats. Blood samples were collected at 1, 2, 4, 8 and 12 h post-administration, and then we measured the concentration of calcium and phosphorus ions in serum.

resultsOsteoporotic rats were divided into eight groups, with 6 rats in each group, with an average weight of 350 g. By studying changes in the concentration of calcium and phosphorus ions in the blood over a period of time, we found that the effect of sCT combined with nifedipine and verapamil in reducing serum calcium and phosphorus was better than that of single drug; the effect of sCT combined with diltiazem in reducing serum calcium was better than that of single drug, and the effect of reducing blood phosphorus was not as good as that of single drug.

conclusionsWe have studied and found that the group of sCT combined with nifedipine group has the most significant effect on reducing calcium and phosphorus in the blood of osteoporotic rats. The effect was significantly better than salmon calcitonin alone. That provided a new medication method for postmenopausal women with osteoporosis. CLINICAL TRIAL NUMBER: Not applicable.

Indexed as

CalcitoninCalciumCalcium Channel BlockersOsteoporosisPhosphorusAnimalsDiltiazemDrug Therapy, CombinationFemaleNifedipineRatsRats, Sprague-DawleyVerapamilCalcitoninCalciumCalcium Channel BlockersDiltiazemNifedipinePhosphorussalmon calcitoninVerapamilDiltiazemDrugs combinationNifedipineOsteoporosisSalmon calcitoninVerapamil

Identifiers

PMID39966992
PMCPMC11834539

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.