ArticleJournal of nanobiotechnology2025
Modulating metal-organic frameworks by surface engineering of stearic acid modification for follicular drug delivery and enhanced hair growth promotion.
Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- The Trilogy of Skin Regeneration via Metal-Organic Frameworks Nanomedicine: Precision Management of Refractory Wounds, Pathological Scarring, and Hair Follicle Reactivation.International journal of nanomedicine · 2025Review
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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Cyclodextrin metal-organic frameworks (CD-MOF) as delivery carriers have gained great attention in the biomedical field. However, limited by challenges of moisture-sensitive nature, the design and application of CD-MOF-based hair follicle delivery for androgenic alopecia (AGA) has rarely been explored. We developed the metal-organic frameworks as hair follicle-targeted delivery system (SA-MOF), stearic acid (SA) was used to modify metal-organic frameworks to form a protective hydrophobic layer on the surface and provide the additional hair growth-promoting effect. Cardamonin (CAR), a newly discovered biosafety natural product, was encapsulated in SA-MOF (CAR@SA-MOF) to promote the therapeutic efficacy on AGA. CD-MOF surface-engineered nanoparticles modified by SA avoided the rapid hydration and disintegration of CD-MOF in water, which improved the drug release and follicular deposition of drug. Assisted by the delivery of SA-modified CD-MOF carriers, the drug significantly promoted cell proliferation and migration, achieving the promoting effect on hair follicle differentiation and hair regeneration in testosterone-challenged C57BL/6 mice. Simultaneously, SA modification provided additional promoting effects on human dermal papilla cell proliferation, regulating effect on keratinocyte growth factor, and activating effect of key signaling pathways. The surface engineering design of CD-MOF hair follicle drug delivery based on SA modification exhibits significant potential for the treatment of hair follicle and sebaceous gland-related diseases.
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