ArticleEarly intervention in psychiatry2025
A Latent Profile Analysis of Psychosis Symptoms to Examine Distress and Depression as Pathways to Suicide Ideation Among Individuals in an Early Phase of Psychosis Illness.
Article in Early intervention in psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundSuicide rates are high among individuals in first episode psychosis and there is a critical need to better understand drivers of suicide risk to inform treatment efforts. This study identified profiles of psychosis symptoms and examined a mediation model of depression and distress as mechanisms in the relationships between psychosis symptoms and suicide ideation by latent profiles.
methodsData were obtained from the Human Connectome Project for Early Psychosis (n = 166) of individuals between 16 and 35 years of age who had onset of affective or non-affective psychosis within 5 years of consent. Data were analysed using Latent Profile Analysis (LPA) and Structural Equation Modelling in MPlus.
resultsLPA revealed the following groups: (1) relatively lower and more balanced levels of symptoms, (2) highest positive and general symptoms and (3) highest negative symptoms. Findings indicated the relationships in the model differed between by LPA groups. Distress and depression functioned as mediators between psychosis symptoms and suicide ideation for Groups 1 and 2.
conclusionsA better understanding of the roles that distress and depression play in the relationships between psychosis symptoms and suicide ideation can help inform modifiable targets of early intervention and subsequently decrease risk for suicide.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.