Evidence map›Paper›PMID 39966948›Full record

ArticleWorld journal of surgical oncology2025

Incidence trends of surgical complications after oesophagectomy for oesophageal cancer: a population-based, nationwide cohort study in Finland over 30 years.

Ville E J Sirviö, Jari V Räsänen, Olli Helminen, Mika Helmiö, Heikki Huhta, Raija Kallio, Vesa Koivukangas, Arto Kokkola, Simo Laine, Elina Lietzen and 11 more

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Article in World journal of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

21 authors.

Ville E J SirviöDepartment of Oesophageal and General Thoracic Surgery, Helsinki University Hospital, University of Helsinki, Haartmaninkatu 4 PL 340, Helsinki, 00029 HUS, Finland. ville.ej.sirvio@helsinki.fi.
Jari V RäsänenDepartment of Oesophageal and General Thoracic Surgery, Helsinki University Hospital, University of Helsinki, Haartmaninkatu 4 PL 340, Helsinki, 00029 HUS, Finland.
Olli HelminenSurgery Research Unit, Oulu University Hospital, University of Oulu, Oulu, Finland.
Mika HelmiöThe Division of Digestive Surgery and Urology, Turku University Hospital and University of Turku, Turku, Finland.
Heikki HuhtaSurgery Research Unit, Oulu University Hospital, University of Oulu, Oulu, Finland.
Raija KallioDepartment of Oncology and Radiotherapy, Oulu University Hospital, Oulu, Finland.
Vesa KoivukangasSurgery Research Unit, Oulu University Hospital, University of Oulu, Oulu, Finland.
Arto KokkolaDepartment of Surgery, University of Helsinki, Helsinki University Hospital, Helsinki, Finland.
Simo LaineThe Division of Digestive Surgery and Urology, Turku University Hospital and University of Turku, Turku, Finland.
Elina LietzenThe Division of Digestive Surgery and Urology, Turku University Hospital and University of Turku, Turku, Finland.
Sanna MeriläinenSurgery Research Unit, Oulu University Hospital, University of Oulu, Oulu, Finland.
Vesa-Matti PohjanenCancer and Translational Medicine Research Unit, Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland.
Tuomo RantanenDepartment of Surgery, University of Eastern Finland, Kuopio University Hospital, Kuopio, Finland.
Ari RistimäkiDepartment of Pathology and HUS Diagnostic Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Juha SaarnioSurgery Research Unit, Oulu University Hospital, University of Oulu, Oulu, Finland.
Eero SihvoDepartment of Surgery, Central Finland Central Hospital, Jyväskylä, Finland.
Vesa ToikkanenDepartment of Cardiothoracic Surgery, Heart Center, Tampere University Hospital, University of Tampere, Tampere, Tampere, Finland.
Tuula TyrväinenDepartment of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland.
Mikko UimonenDepartment of Surgery, Central Finland Central Hospital, Jyväskylä, Finland.
Antti ValtolaDepartment of Surgery, University of Eastern Finland, Kuopio University Hospital, Kuopio, Finland.
Joonas H KauppilaSurgery Research Unit, Oulu University Hospital, University of Oulu, Oulu, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundKnowledge on the incidence of surgical complications after oesophagectomy for oesophageal cancer in nationwide practice is scarce. The aim of this study was to assess complication trends after oesophagectomy in a nationwide, population-based, unselected cohort.

methodsAll patients undergoing oesophagectomy for oesophageal cancer in Finland in 1987-2016 were included. All complications defined by the Esophagectomy Complications Consensus Group (ECCG) were reported in three 10-year periods. Chi-square test and Kruskal-Wallis test were used to compare outcomes in these periods.

resultsA total of 1493 patients were included. From 1987 to 1996 to 2007-2016, improvements were seen in the rate of major complications (49% vs. 43%, p = 0.039), length of hospital stay (19 vs. 14 days, median, p < 0.001), length of ICU-stay (3 vs. 2 days, median, p < 0.001) and 90-day mortality (17.9% vs. 5.4%, p < 0.001), while pneumonia (16% vs. 23%, p = 0.029) and anastomotic leak (8% vs. 12% in total leaks, p = 0.006 for type II leak) increased. The most common complications were pneumonia, pleural effusion requiring drainage (16% vs. 23%, p = 0.080), atrial dysrhythmia (16% vs. 15%, p = 0.464) and anastomotic leak. The most common complication categories defined by ECCG were pulmonary (36% vs. 42%, p = 0.151) and gastrointestinal (21% vs. 23%, p = 0.398) complications.

conclusionsThis study reports high postoperative morbidity after oesophagectomy in nationwide practice. Mortality has significantly improved during the years, and it appears that patients who would have died earlier, can now be rescued. While the relative occurrence of complications has remained constant, overall morbidity has decreased as the more severe outcomes have decreased.

Indexed as

Esophageal NeoplasmsEsophagectomyPostoperative ComplicationsAdultAgedAged, 80 and overAnastomotic LeakCohort StudiesFemaleFinlandFollow-Up StudiesHumansIncidenceLength of StayMaleMiddle AgedMorbidityMortalityNationwide cohortOesophageal cancerOesophagectomySurgical complications

Identifiers

PMID39966948
PMCPMC11834619

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.