SynthesisBMC oral health2025
Optimal treatment time with systemic antimicrobial therapy in odontogenic infections affecting the jaws: a systematic review.
Synthesis in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Reassessing Antibiotic Duration in Dental Infections: A Narrative Review and Marginal Benefit-Harm Framework with a Clinical Checklist.Antibiotics (Basel, Switzerland) · 2026Review
- How Clinical and Radiological Findings in Chronic Mandibular Osteomyelitis Do Not Always Correlate: Diagnostic Dilemmas in Dental-Related Bone Inflammations.Diagnostics (Basel, Switzerland) · 2026Article
- Infraorbital extension of odontogenic infection mimicking dacryocystitis.Journal of conservative dentistry and endodontics · 2026Article
- Article
- Canada's "American-style" dental health system.Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2025Article
- Optimal Duration of Antibiotic Therapy for Space Infections in the Maxillofacial Region: A Systematic Review.Craniomaxillofacial trauma & reconstruction · 2025Review
- Histological Analysis of Root Surface Treatment with Tetracycline and Ampicillin in the Repair Process of Rat Teeth Subjected to Delayed Replantation.Journal of clinical medicine · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis systematic review aimed to analyze the existing literature to determine the most effective and safe duration of antimicrobial treatment in odontogenic infections of the mandible, addressing a critical gap in clinical guidelines regarding optimal treatment duration. MATERIALS AND
methodsA systematic review protocol was registered in PROSPERO (CRD42024551258), and a comprehensive search was conducted in databases including PubMed, Web of Science, Scopus, ScienceDirect, Embase, and Google Scholar for articles published up to June 16, 2024. Randomized clinical trials (RCTs) evaluating different durations of antimicrobial treatment were prioritized.
resultsThe database search yielded 3,446 articles. After removing duplicates using Rayyan© software, 2,653 articles remained, of which 26 met the inclusion criteria. Following a thorough evaluation, 8 studies were deemed highly relevant and included in the final analysis. The findings suggest that shorter antibiotic regimens, typically ranging from 3 to 5 days, are effective when combined with surgical interventions, minimizing complications and bacterial resistance.
conclusionsThe evidence indicates that the choice of antibiotic regimen and its duration should be tailored to the patient's clinical condition, the severity of the infection, and local bacterial resistance patterns. While amoxicillin and its derivatives are effective for most cases, alternative antibiotics such as ciprofloxacin or metronidazole may be more suitable in specific scenarios. These findings highlight the importance of individualized treatment plans and the need for further randomized clinical trials to refine evidence-based guidelines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.