Evidence map›Paper›PMID 39966830›Full record

SynthesisBMC endocrine disorders2025

Ramadan fasting among adolescents with type 1 diabetes: a systematic review and meta-analysis.

Omid Safari, Arman Shafiee, Afshin Heidari, Fatemeh Nafarzadeh, Dlnya Aminzadeh, Fatemeh Esmaeilpur Abianeh, Mohammad Javad Amini, Mahmood Bakhtiyari, Ayad Bahadori Monfared

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in BMC endocrine disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Omid Safari *Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran.
Arman Shafiee *Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran. armanshafieemd@gmail.com.
Afshin HeidariSchool of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Fatemeh NafarzadehStudent Research Committee, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran.
Dlnya AminzadehStudent Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Fatemeh Esmaeilpur AbianehStudent Research Committee, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Mohammad Javad AminiStudent Research Committee, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran.
Mahmood BakhtiyariNon-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran.
Ayad Bahadori MonfaredNon-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran. dr.a.bahadori@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis systematic review and meta-analysis assess the effects of Ramadan fasting in adolescents with type 1 diabetes mellitus (T1DM), on blood sugar factors such as hemoglobin A1C and problems caused by its lack of control such as hypoglycemia and DKA, and metabolic outcomes.

methodsElectronic databases including MEDLINE, Embase, and SINOMED were searched up to February 13, 2024, without language, region, or publication time restrictions. The outcomes were Acute complications, changes in Hemoglobin A1c (HbA1c) and weight changes. Meta-analyses used random-effects models to compute weighted Relative risk (RR) and standard mean differences (SMD). And to check the risk of bias of included studies, the Newcastle-Ottawa scale was used.

resultsNine studies were included, comprising 458 participants, with studies varying in quality from high to low. Meta-analysis showed no significant reduction in HbA1c levels post-Ramadan (SMD: -0.12; 95% CI: -0.38 to 0.14), indicating minimal impact on long-term glycemic control. The incidence of hypoglycemia was notably high (50.79 events per 100 observations), with hyperglycemia and diabetic ketoacidosis (DKA) also reported but less frequently. The variability in complication rates among studies was significant, reflecting the high heterogeneity across the data. Weight changes during Ramadan were minimal and not statistically significant, suggesting fasting's negligible effect on body weight among participants.

conclusionsRamadan fasting among adolescents with T1DM does not significantly alter HbA1c levels, suggesting potential feasibility under careful monitoring and management. However, the high incidence of hypoglycemia underscores the need for vigilant glucose monitoring and tailored adjustments to diabetes management plans during fasting periods.

Indexed as

Diabetes Mellitus, Type 1FastingIslamAdolescentBlood GlucoseDiabetic KetoacidosisGlycated HemoglobinHumansHypoglycemiaBlood GlucoseGlycated Hemoglobinhemoglobin A1c protein, humanAdolescentsFastingMeta-analysisRamadanType 1 diabetes mellitus

Identifiers

PMID39966830
PMCPMC11834623

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.