ArticleBMC women's health2025
The application of progesterone-primed ovarian stimulation protocol in patients with ovarian endometriosis combined with diminished ovarian reserve.
Article in BMC women's health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Evaluating progestin-primed and GnRH antagonist ovarian stimulation protocols in PGT-A cycles: implications for clinical practice.BMC pregnancy and childbirth · 2026Article
- Endometriosis-Associated Infertility: A Review of Pathophysiological Mechanisms and Current Treatment Strategies.Journal of clinical medicine · 2026Review
- A retrospective cohort study comparing controlled ovarian stimulation protocols for IVF/ICSI in women with endometriosis and diminished ovarian reserve.Frontiers in endocrinology · 2026Article
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim was to investigate the value of the application of a progesterone-primed ovarian stimulation (PPOS) protocol in patients with ovarian endometriosis (OEM) combined with diminished ovarian reserve (DOR). MATERIALS AND
methodsA retrospective analysis of 95 patients with OEM combined with a DOR who underwent in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET) was conducted between March 2020 and February 2024 at the Reproductive Center of Xuzhou Central Hospital. Patients were divided into two groups on the basis of the ovarian stimulation protocol used: the PPOS group (n = 60, 60 cycles) and the GnRH agonist downregulation group (n = 35, 35 cycles). General data, ovarian stimulation outcomes, and pregnancy outcomes were compared between the two groups.
resultsThere were no statistically significant differences between the two groups in terms of general data (P > 0.05). Compared with the PPOS group, the GnRH agonist group presented significantly more Gn days and higher Gn dosages (P < 0.05). However, there were no significant differences between the groups in terms of the number of oocytes retrieved, metaphase II oocyte rate, fertilization rate, cleavage rate, high-quality embryo rate, or cycle cancellation rate (P > 0.05). Additionally, no significant differences were observed in the embryo transfer parameters, endometrial thickness, embryo implantation rate, clinical pregnancy rate, ectopic pregnancy rate, or early miscarriage rate (P > 0.05).
conclusionsIn patients with OEM combined with DOR, the PPOS protocol had pregnancy outcomes comparable to those of the downregulation protocol, with the added advantage of being more cost-effective.
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