Evidence map›Paper›PMID 39966749›Full record

ArticleBMC endocrine disorders2025

Age at type 1 diabetes onset does not influence attained brain volume.

Tor-Björn Claesson, Stefan Mutter, Jukka Putaala, Eero Salli, Daniel Gordin, Per-Henrik Groop, Juha Martola, Lena M Thorn

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC endocrine disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tor-Björn ClaessonDepartment of Radiology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Stefan MutterFolkhälsan Research Centre, Helsinki, Finland.
Jukka PutaalaDepartment of Neurology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Eero SalliDepartment of Radiology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Daniel GordinDepartment of Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Per-Henrik GroopFolkhälsan Research Centre, Helsinki, Finland.
Juha Martola *Department of Radiology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Lena M Thorn *Folkhälsan Research Centre, Helsinki, Finland. lena.thorn@helsinki.fi.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionType 1 diabetes is suspected to hamper brain growth, implying that people with earlier diabetes onset would, on average, achieve lower maximal brain volume. We set out to test this hypothesis.

methodsExamining brain MRI scans of middle-aged people with type 1 diabetes, we related age at diabetes onset to intracranial volume in 180 participants, as well as to cerebral gray and white matter volumes in a subset of 113 (63%) participants, using fractional polynomial regression models. Of the participants, 118 (67%) had been diagnosed with diabetes before 18 years of age.

resultsOf our participants, 54% were women, the median age 40.0 (IQR 33.2-45.0) years and the range of age at diabetes onset was 1.2-39.0 years. We found no association between age at diabetes onset and intracranial volume (p = 0.85), cerebral white (p = 0.10), or gray matter volumes (p = 0.12). Further, correlations between age at diabetes onset and the measured brain volumes were poor in analyses stratified for sex (all correlation coefficients ρ ≤ 0.16).

conclusionsWe found no association between age at diabetes onset and attained intracranial volume or gray or white matter volumes, indicating that type 1 diabetes may not have a clinically significant influence on brain growth.

Indexed as

BrainDiabetes Mellitus, Type 1AdolescentAdultAge of OnsetFemaleFollow-Up StudiesGray MatterHumansMagnetic Resonance ImagingMaleMiddle AgedOrgan SizePrognosisWhite MatterYoung AdultAge of onsetBrainDiabetes mellitus, type 1Gray matterMagnetic resonance imagingWhite matter

Identifiers

PMID39966749
PMCPMC11834590

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.